Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract

Sun Baoliang; Xia Zuoli; Zheng Chengbi; Li Wenxia; Fang Yuzhen

doi:10.1007/BF02935404

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Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract

Updated：2021-08-27

- Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract
- Chinese Journal of Integrative Medicine Vol. 5, Issue 4, Pages: 279-282(1999)
- Affiliations：
  
  Department of Neurology, Institute of Microcirculation, Affiliated Hospital of Taishan Medical College, Shangdong
- Author bio：
- Funds：
- DOI：10.1007/BF02935404
  CLC：
- Published：1999，
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Baoliang, S., Zuoli, X., Chengbi, Z. et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract., CJIM 5, 279–282 (1999). https://doi.org/10.1007/BF02935404

Sun Baoliang, Xia Zuoli, Zheng Chengbi, et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract. [J]. Chinese Journal of Integrative Medicine 5(4):279-282(1999)
Baoliang, S., Zuoli, X., Chengbi, Z. et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract., CJIM 5, 279–282 (1999). https://doi.org/10.1007/BF02935404 DOI：

Sun Baoliang, Xia Zuoli, Zheng Chengbi, et al. Relationship between endothelin-1 and ischemic brain damage after subarachnoid hemorrhage and protective effect of Ginkgo biloba extract. [J]. Chinese Journal of Integrative Medicine 5(4):279-282(1999) DOI： 10.1007/BF02935404.

摘要

Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH)

and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group

the diameter of basilar artery (BA)

dynamic changes of regional cerebral blood flow (rCBF) and ET-1 content of in-tracranial plasma within 24 hours after SAH of both groups were determined. And pathological examination of CA1 region of hippocampus was performed 3 days later.Results: rCBF decreased and ET-1 content increased obviously and steadily in 24 hours after SAH. Spasm of BA occurred half an hour after SAH and neurons of hippocampus CA1 region were damaged severely. GBE could antagonize the above-mentioned pathological changes effectively

Abstract

Objective: To investigate the role of endothelin-1 (ET-1) in development of ischemic brain damage after subarachnoid hemorrhage (SAH)

and the protective effect of Ginkgo biloba extract (GBE) on it.Methods: Noncraniotomy SAH models of Wistar rat were divided into SAH group and GBE treated group

the diameter of basilar artery (BA)

关键词

subarachnoid hemorrhagecerebral vasospasmIschemic Brain DamageendothelinGinkgo Biloba Extract

Keywords

subarachnoid hemorrhagecerebral vasospasmIschemic Brain DamageendothelinGinkgo Biloba Extract

references

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Department of Microbiology, Capital Medical University

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