Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats

Liu Hedi; Li En

doi:10.1007/BF02935405

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Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats

Updated：2021-08-27

- Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats
- Chinese Journal of Integrative Medicine Vol. 5, Issue 4, Pages: 283-287(1999)
- Affiliations：
  
  Department of Biochemistry, Hebei Medical University, Shijiazhtiang,050017
- Author bio：
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- DOI：10.1007/BF02935405
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- Published：1999，
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Hedi, L., En, L. Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats., CJIM 5, 283 (1999). https://doi.org/10.1007/BF02935405

Liu Hedi, Li En. Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats. [J]. Chinese Journal of Integrative Medicine 5(4):283-287(1999)
Hedi, L., En, L. Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats., CJIM 5, 283 (1999). https://doi.org/10.1007/BF02935405 DOI：

Liu Hedi, Li En. Influence of replenishing Kidney herbs on osteoporosis induced by dexamethasone and retinoic acid in rats. [J]. Chinese Journal of Integrative Medicine 5(4):283-287(1999) DOI： 10.1007/BF02935405.

摘要

Objective: To explorate the influence of replenishing Kidney herbs on dexamethasone (DXM) or retinoic acid (RA) induced osteoporosis in rats.Methods: Model animal of osteoporosis was made by DXM injection or RA through gastrogavage

and some animals received replenishing Kidney herbs during modelling. Changes of serum calcium

phosphate

alkaline phosphatase (ALP)

estrogen (E)

prostaglandin E2(PGE2)

25-dihydroxyvitamin D3(VD3)

uric hydroxyproline (UHP)

intestinal calcium absorption

bone ash weight

bone density

bone histopathology as well as the change of intestinal calcium absorption vector-Ca-binding protein D9K (CaBp-D9K) gene and its mRNA expression were examined and compared.Results: DXM or RA could markedly induce bone metabolism disorder

showed as morphologic and histologic changes of bone

in DXM group

decrease of E2

VD3

bone density

bone ash weight

intestinal calcium absorption

increase of PGE2

and in RA group

decrease of serum E2

calcium

phosphate

ALP

UHP

bone density

bone ash weight

and intestinal calcium absorption. These changes could be reduced significantly when rats received replenishing Kidney herbs during modelling

and approached to normal.Conclusion: Osteoporosis induced by long-term application of DXM and low calcium diet feeding is a good animal model for experimental research. Replenishing Kidney herbs could significantly improve bone metabolism disorder induced by DXM or RA

Abstract

and some animals received replenishing Kidney herbs during modelling. Changes of serum calcium

phosphate

alkaline phosphatase (ALP)

estrogen (E)

prostaglandin E2(PGE2)

25-dihydroxyvitamin D3(VD3)

uric hydroxyproline (UHP)

intestinal calcium absorption

bone ash weight

bone density

showed as morphologic and histologic changes of bone

in DXM group

decrease of E2

VD3

bone density

bone ash weight

intestinal calcium absorption

increase of PGE2

and in RA group

decrease of serum E2

calcium

phosphate

ALP

UHP

bone density

bone ash weight

and intestinal calcium absorption. These changes could be reduced significantly when rats received replenishing Kidney herbs during modelling

关键词

Osteoporosisdexamethasoneretinoic acidreplenishing Kidney herb

Keywords

Osteoporosisdexamethasoneretinoic acidreplenishing Kidney herb

references

Liang CT. Alteration of duodenal vitamin D dependent calcium-binding protein content and calcium uptake in brush border membrane vesicles in aged Wistar rats: role of 1, 25- (OH)2-P3. Endocri 1991; 128(4): 1780.

Krisinger J, Darwish H, Marda N. Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene. Proc Natl Acad Sci USA 1988; 85: 8988.

Johnston CC Jr, Slemenda CW. Pathogenesis of osteoporosis. Bone 1995; 17(2 suppl): S19–22.

Lukert BP, Raisz LG. Glucocorticoid-induced osteoporosis: pathogenesis and management. Ann Inter Med 1990; 112 (5): 352–364.

Riggs BL. The prevention and treatment of osteoporosis. N Engl J Med 1992; 327: 620–627.

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