Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy

Wang Xian-Bo; Sang Yan; Han Qing; Guo Bao-Rui; Liu Xi-Xin

doi:10.1007/BF02935430

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Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy

Updated：2021-08-27

- Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy
- Chinese Journal of Integrative Medicine Vol. 3, Issue 1, Pages: 21-25(1997)
- Affiliations：
  
  The First Affiliated Hospital of Xinxiang Medical College,Henan
- Author bio：
- Funds：
  
  Grant from Bureau of TCM of Henan Province
- DOI：10.1007/BF02935430
  CLC：
- Published：1997，
Scan for full text
Wang, XB., Sang, Y., Han, Q. et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy., CJIM 3, 21 (1997). https://doi.org/10.1007/BF02935430

Wang Xian-Bo, Sang Yan, Han Qing, et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy. [J]. Chinese Journal of Integrative Medicine 3(1):21-25(1997)
Wang, XB., Sang, Y., Han, Q. et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy., CJIM 3, 21 (1997). https://doi.org/10.1007/BF02935430 DOI：

Wang Xian-Bo, Sang Yan, Han Qing, et al. Effects of Tangshenkang capsule on diabetic nephropathyon diabetic nephropathy. [J]. Chinese Journal of Integrative Medicine 3(1):21-25(1997) DOI： 10.1007/BF02935430.

摘要

Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN).Method: Fifty-seven patients with DN were randomly divided into two groups

the TSK-treated group and the control group-Results: Serious disorders of metabolism showed in DN patients

displayed high levels of thromboxane B2/6-keto-prostaglandin F1α(TXB2/6-keto-PGFlα) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK

the urinary albumin level reduced obviously (by 51%)

renal plasma flow (RPF) increased

glomerular filtration rate and LPO levels decreased. A positive correlation was observed between albuminuria level and TXB2/6-keto-PGFlα ratio. The clearance rate of creatinine didn’t improve significantly. In the control group

no significant difference in the above-mentioned parameters between pre-treatment and post-treatment was found.Conclusion: TSK capsule possessed a significant effect in improving urinary albumin and glomerular function. These effects might be due to the property of TSK in adjusting TXB2/6-keto-PGFlα ratio and its lipid-peroxidation in DN patients.

Abstract

Objective: To study the effects of Chinese herbal medicine Tangshenkang (TSK) capsule on diabetic nephropathy (DN).Method: Fifty-seven patients with DN were randomly divided into two groups

the TSK-treated group and the control group-Results: Serious disorders of metabolism showed in DN patients

displayed high levels of thromboxane B2/6-keto-prostaglandin F1α(TXB2/6-keto-PGFlα) ratio and lipid peroxide (LPO) as compared with those of healthy persons. After 6 weeks treatment with TSK

the urinary albumin level reduced obviously (by 51%)

renal plasma flow (RPF) increased

关键词

Tangshenkang capsulediabetic nephropathythromboxane B26-keto-prostaglandin Flα1lipid peroxide

Keywords

Tangshenkang capsulediabetic nephropathythromboxane B26-keto-prostaglandin Flα1lipid peroxide

references

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1989;9(1): 46–47.

Anderson S. Pathogenesis of diabetic glomerulopathy: Hemodynamic considerations. Diabetes Metab Rev 1988; 4: 163–165.

1989: 565–566.

1994;10(1): 19–21.

1991; 31(7): 402–404.

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Department of Pharmacy, College of Chemical and Chemistry Engineering, Hu’nan University

Department of Basic Guiyang College of Traditional Chinese Medicine

Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology

Zhejiang University of Traditional Chinese Medicine

Dongzhimen Hospital, Beijing University of Chinese Medicine

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