Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits

Li Ming-Zhen; Ye Wang-Yun; Luo Ming; Wu Chao-Dong; Yang Guang; Wang Kai-Fu; Lin Bao-Ying; Zhang Yan-Ping; Xu Li-Jun; Wen Zi-Jian

doi:10.1007/BF02935437

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Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits

Updated：2021-08-27

- Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits
- Chinese Journal of Integrative Medicine Vol. 3, Issue 1, Pages: 40-45(1997)
- Affiliations：
  
  1. Institute of Integration of Traditional and Western Medicine, Tongji Medical University,Wuhan
  2. Searle-Monsanto Co., Chesterfield,USA
- Author bio：
- Funds：
  
  Grant from State Administration of TCM
- DOI：10.1007/BF02935437
  CLC：
- Published：1997，
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Li, MZ., Ye, WY., Luo, M. et al. Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits., CJIM 3, 40–45 (1997). https://doi.org/10.1007/BF02935437

Li Ming-Zhen, Ye Wang-Yun, Luo Ming, et al. Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits. [J]. Chinese Journal of Integrative Medicine 3(1):40-45(1997)
Li, MZ., Ye, WY., Luo, M. et al. Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits., CJIM 3, 40–45 (1997). https://doi.org/10.1007/BF02935437 DOI：

Li Ming-Zhen, Ye Wang-Yun, Luo Ming, et al. Effect of Reduqing on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits) on TNF-α, IL-1, IL-6, IL-8 and PAF levels in endotoxin-lnduced DIC model of rabbits. [J]. Chinese Journal of Integrative Medicine 3(1):40-45(1997) DOI： 10.1007/BF02935437.

摘要

Objective: To study the mechanism of anti-endotoxemic effect of Reduqing Injection (RDQ) and to explore the essence of traditional Chinese “heat-clearing and detoxifying therapy”.Methods: A disseminated intravascular coagulation (DIC) model was made in rabbits by intravenous injection with E. coli endotoxin. Increased plasma levels of tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

interleukin-8 (IL-8) and platelet activating factor (PAF)

as well as the ex-vivo LPS-induced interleukin-1 (IL-1) production in peripheral blood monocytes were observed in model (M) group.Results: Same parameters were significantly lower in RDQ and dexamethasone (DXM) groups than those in the M group (P<0.01

P<0.05). Histopathological examination showed severe damage of the liver

lungs and kidneys in the rabbits of M group

in contrast

only mild affects were seen in the RDQ and DXM groups.Conclusions: RDQ exhibits protective effect on rabbits against endotoxin-induced DIC. The suppression of cytokines and inflammatory mediator PAF by RDQ may play a central role in the inhibition of endotoxin-induced DIC cascade.

Abstract

interleukin-6 (IL-6)

interleukin-8 (IL-8) and platelet activating factor (PAF)

P<0.05). Histopathological examination showed severe damage of the liver

lungs and kidneys in the rabbits of M group

in contrast

关键词

endotoxindisseminated intravascular coagulationtumor necrosis factor-ainterleukin-1interleukin-6interleukin-8platelet activating factor

Keywords

endotoxindisseminated intravascular coagulationtumor necrosis factor-ainterleukin-1interleukin-6interleukin-8platelet activating factor

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Institute of Integrated Traditional Chinese and Western Medicine, Tongji Medical University

Searle-Monsanto Co.

Institution of Integration of Traditional Chinese and Western Medicine, Tongji Medical University

Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University

Beijing Institute of Traditional Chinese Medicine

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