Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo

Feng Wei-Hong; Hou Jia-Yu

doi:10.1007/BF02935438

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Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo

Updated：2021-08-27

- Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo
- Chinese Journal of Integrative Medicine Vol. 3, Issue 1, Pages: 46-50(1997)
- Affiliations：
  
  Department of Pharmacology, Beijing University of TCM,Beijing
- Author bio：
- Funds：
  
  Article of National Foundation of Natural Science
- DOI：10.1007/BF02935438
  CLC：
- Published：1997，
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Feng, WH., Hou, JY. Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo., CJIM 3, 46–50 (1997). https://doi.org/10.1007/BF02935438

Feng Wei-Hong, Hou Jia-Yu. Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo. [J]. Chinese Journal of Integrative Medicine 3(1):46-50(1997)
Feng, WH., Hou, JY. Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo., CJIM 3, 46–50 (1997). https://doi.org/10.1007/BF02935438 DOI：

Feng Wei-Hong, Hou Jia-Yu. Effect of Shashen Maidong Decoction on gastric motility in vivo) on gastric motility in vivo. [J]. Chinese Journal of Integrative Medicine 3(1):46-50(1997) DOI： 10.1007/BF02935438.

摘要

Objective: To evaluate the effect of Shashen Maidong Decoction (SSMDD) on gastric motility.Method: Effect of SSMDD on the gastric motility of mice and rats was observed in vivo by administration of SSMDD in various dosages and observation on gastric phenol red excretion rate

gastric emptying rate

frequency and amplitude of contraction of fundic longitudinal muscles

etc.Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice

antagonize the acceleration of gastric emptying induced by neostigmine

inhibit the frequency and amplitude of contraction of fundic longitudinal muscle

slow down the frequency and decrease the amplitude of gastric peristalsis

and reduce the gastric hypermotility induced by indomethacin significantly.Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo

its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E.

Abstract

gastric emptying rate

frequency and amplitude of contraction of fundic longitudinal muscles

etc.Results: SSMDD could reduce markedly the gastric phenol red excretion rate of mice

antagonize the acceleration of gastric emptying induced by neostigmine

inhibit the frequency and amplitude of contraction of fundic longitudinal muscle

slow down the frequency and decrease the amplitude of gastric peristalsis

and reduce the gastric hypermotility induced by indomethacin significantly.Conclusion: SSMDD has evident inhibition action on motility of experimental animals in vivo

its mechanism might be related with adrenergic nerve and metabolism of prostaglandin E.

关键词

Shashen Maidong Decoctiongastric emptyingingastric pressurefundic longitudinal muscleantral circular muscleIndomethacinReserpine

Keywords

Shashen Maidong Decoctiongastric emptyingingastric pressurefundic longitudinal muscleantral circular muscleIndomethacinReserpine

references

1994; 17(4): 50–52.

1989;9 (1): 31–32.

Takeuchi K, Ueki S, Okabe S. Importance of gastric motility in the pathogenesis of indomethacin induced gastric lesions in rats. Dig Dis Sci 1986; 31(10): 1114–1122.

Mersereau WA, Hinchey EJ. Synergism between acid and gastric contractile activity in the genesis of ulceration and hemorrhage in the phenylbutazone treated rat. Surgery 1981: 90:516–522.

Okada M, Niida H, Takeuchi K, et al. Role of prostaglandin deficiency in pathogenetic mechanism of gastric lesions induced by indomethacin in rats. Dig Dis sci 1989: 34(5): 694–702.

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Related Institution

Department of Gastroenterology, Shengjing Hospital of China Medical University

The Hospital of PLA

Institute of Chinese Material Medica, China Academy of TCM

Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University, Weihui

Department of Stomatology, the First Affiliated Hospital of Xinxiang Medical University, Weihui

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