Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

Duan Shaobin; Luo Ji’an; Liu Ruihong; Xu Xiping

doi:10.1007/BF02935483

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Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure

Updated：2021-08-27

- Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure
- Chinese Journal of Integrative Medicine Vol. 4, Issue 4, Pages: 290-292(1998)
- Affiliations：
  
  1. The Second Affiliated Hospital of Hunan Medical University,Changsha
  2. Department of Electron Microscope, Hunan Medical University,Changsha
- Author bio：
- Funds：
  
  This work was supported by the grant from the Health Administration of Hunan Province
- DOI：10.1007/BF02935483
  CLC：
- Published：1998，
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Shaobin, D., Ji’an, L., Ruihong, L. et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure., CJIM 4, 290–292 (1998). https://doi.org/10.1007/BF02935483

Duan Shaobin, Luo Ji’an, Liu Ruihong, et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure. [J]. Chinese Journal of Integrative Medicine 4(4):290-292(1998)
Shaobin, D., Ji’an, L., Ruihong, L. et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure., CJIM 4, 290–292 (1998). https://doi.org/10.1007/BF02935483 DOI：

Duan Shaobin, Luo Ji’an, Liu Ruihong, et al. Protective effect of Shengmai Injection on rats with contrast medium-associated acute renal failure) on rats with contrast medium-associated acute renal failure. [J]. Chinese Journal of Integrative Medicine 4(4):290-292(1998) DOI： 10.1007/BF02935483.

摘要

Objective: Radiographic contrast media can induce renal failure and it may serve as an experimental model of acute renal failure (ARF). The study was aimed to determine the protective effect of Shengmai Injection (SMI) on contrast medium-associated ARF in Sprague-Dawley (SD) rats.Methods: Twenty healthy SD rats of both sex were randomly divided into two groups

Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate

and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B

the levels of blood urea nitrogen

serum creatinine

renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A

P < 0.01. The results indicated the renal injury induced by meglucamine diatrizoate was alleviated by SMI.Conclusion: SMI could prevent renal tissue from contrast media induced nephropathy in SD rats. The effect may partially owe to its preventing intracellular calcium accumulation

inhibiting PLA2 activity and dilating renal vessels.

Abstract

Group A (control group) treated with glycerin+0. 9% saline+meglucamine diatrizoate

and group B (preventive group) with glycerin+SMI+meglucamine diatrizoate.Results: In Group B

the levels of blood urea nitrogen

serum creatinine

renal phospholipase A2 (PLA2) and calcium were all significantly lower than those in Group A

inhibiting PLA2 activity and dilating renal vessels.

关键词

nephrotoxicitycontrast mediaShengmai Injectionrenal failuremeglucamine diatrizoate

Keywords

nephrotoxicitycontrast mediaShengmai Injectionrenal failuremeglucamine diatrizoate

references

Porter GA. Effect of contrast agent on renal function. Invest Radiol 1993; 28: S1-S5.

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Related Institution

Department of Physiology, Bengbu Medical College

Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University

Department of Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine

Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong Medical University School of Medicine

Department of Biochemistry, Hebei Medical University

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