Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia

Tao Yue-yu; Guo Song-duo; Chen Hui-zheng; Hu Hua; Lu Bu-feng; Yan Yu-lan; Lu You-ming

doi:10.1007/BF02940701

Your Location：

Home >

Browse articles >

Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia

Updated：2021-08-27

- Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia
- Chinese Journal of Integrative Medicine Vol. 1, Issue 4, Pages: 288-290(1995)
- Affiliations：
  
  1. Nanjing Hospital of Navy,Nanjing,414
  2. Nanjing Research Center of Neuro-biology of Navy,China
- Author bio：
- Funds：
- DOI：10.1007/BF02940701
  CLC：
- Published：1995，
Scan for full text
Tao, Yy., Guo, Sd., Chen, Hz. et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia., CJIM 1, 288–290 (1995). https://doi.org/10.1007/BF02940701

Tao Yue-yu, Guo Song-duo, Chen Hui-zheng, et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia. [J]. Chinese Journal of Integrative Medicine 1(4):288-290(1995)
Tao, Yy., Guo, Sd., Chen, Hz. et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia., CJIM 1, 288–290 (1995). https://doi.org/10.1007/BF02940701 DOI：

Tao Yue-yu, Guo Song-duo, Chen Hui-zheng, et al. Effects of compound salviae miltiorrhizae injection on metabolism of phosphoinosititides in myocardial ischemia. [J]. Chinese Journal of Integrative Medicine 1(4):288-290(1995) DOI： 10.1007/BF02940701.

摘要

Using the model of acute myocardial ischemia in rats formed by ligation of the descending anterior branch of the left coronary artery

this study showed some effects of compound Salviae miltiorrhizae injection (CSMI) on metabolism of phosphoinositide in myocardial ischemia. The results of the experiment showed that after 10 minutes of acute ischemia

the function of myocardial messangers of phosphoinositide increased

and the levels of phosphatidylinositol-4

5-biphosphate (PIP2) and inositol-1

5-trisphosphate (IP3) were obviously higher than those of the non-ischemia control groups (P<0.01

n=7). CSMI (2 g/kg body weight) could markedly inhibit myocardial PIP2 and IP3

whose levels became lower than those of the ischemia control groups (P<0.01

n=7).

Abstract

Using the model of acute myocardial ischemia in rats formed by ligation of the descending anterior branch of the left coronary artery

the function of myocardial messangers of phosphoinositide increased

and the levels of phosphatidylinositol-4

5-biphosphate (PIP2) and inositol-1

5-trisphosphate (IP3) were obviously higher than those of the non-ischemia control groups (P<0.01

n=7). CSMI (2 g/kg body weight) could markedly inhibit myocardial PIP2 and IP3

whose levels became lower than those of the ischemia control groups (P<0.01

n=7).

关键词

Myocardial ischemiaphophoinositidescompound Salviae miltiorrhizae injection

Keywords

Myocardial ischemiaphophoinositidescompound Salviae miltiorrhizae injection

references

Dun W, et al. Anti-arrhythmia and anti-lipid peroxidation effects of methylflavonolamine. Acta Pharmacol Sin 1991;12:177.

Lowry OH, et al. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:2550.

Willerson JJ, et al. Specific platelet mediators and unstable coronary artery lessions. Circulation 1989;80:198.

James JW, et al. Pathogenesis and pathology of ischemic heart disease. In: James JW, L’Daid H, L’Marimilian B, eds. Ischemic heart disease: clinical and pathophysiological aspects. New York: Raven Press, 1982:7–83.

Hokin LE. Receptors and phosphoinositide-generated second messangers. Am Rev Biolchem 1985;54:205.

Putney JW Jr. Formation and action of calcium-mobilizing messenger, inositol-1, 4, 5-trisphosphate. Am J Physiol 1987;252:G149.

Heathers GP, et al. Enhanced inositol trisphosphates response to alpha 1-adrenergic stimulation in cardiac myocytes exposed to hypoxia. J Clin Invest 1989; 83:1409.

FULL TEXT LINK

More>

Views

776

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Improved mesenchymal stem cell survival in ischemic heart through electroacupuncture

Clinical observation on effect of Kaixin Capsule in treating 40 patients with diabetic myocardial ischemia

Effect of electroacupuncture on heart meridian for change of end-diastolic intraventricular pressure with myocardial ischemia in rabbits

Comparative study on effects of different treatments in preventing myocardial ischemia caused by coronary artery ligation in diabetic rats

Effect of theo-polyphenols ( ) on function of trans-membranous signal system of acute ischemic myocardium in rats) on function of trans-membranous signal system of acute ischemic myocardium in rats

Related Author

No data

Related Institution

Institute of Cardiovascular Diseases, Pingjin Hospital, Medical College of Armed Police Forces

School of Nursing, Guangzhou University of Chinese Medicine

School of Fundamental Medical Sciences, Guangzhou University of Chinese Medicine

State Key Laboratory of Medicinal Chemical Biology, College of Life Science, Nankai University

The First Affiliated Hospital of Guangzhou University of TCM

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰