Zhao, Xz., Liu, Fr. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus., CJIM 1, 111–113 (1995). https://doi.org/10.1007/BF02942761
Zhao Xiao-zhong, Liu Fu-ren. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus. [J]. Chinese Journal of Integrative Medicine 1(2):111-113(1995)
Zhao, Xz., Liu, Fr. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus., CJIM 1, 111–113 (1995). https://doi.org/10.1007/BF02942761DOI:
Zhao Xiao-zhong, Liu Fu-ren. The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus. [J]. Chinese Journal of Integrative Medicine 1(2):111-113(1995) DOI: 10.1007/BF02942761.
The effects ofAstragalus membranaceus andTripterygium hypoglaucum on NK activity in systemic lupus erythematosus
摘要
The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy
but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors.
Abstract
The natural killer cell activity of peripheral blood mononuclear cells from 28 patients with systemic lupus erythematosus was measured using enzyme-release assay. The patients exhibited obviously decreased natural killer cell activity compared with the healthy subjects in the control group. The natural killer cell dysfunction was related to steroidal therapy
but not to three auto-antibodies. The release of a soluble natural killer cytotoxic factor by the peripheral blood mononuclear cells was tested by cytotoxicity assay induced in K562 cells. This release was significantly lower in the test group than in the control group. Pre-incubation of peripheral blood mononuclear cells withAstragalus membranaceus andTripterygium hypoglaucum considerably enhanced natural killer cytotoxicity by stimulating the release of soluble cytotoxic factors.
Tan E, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271.
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Sibbitt E, et al. Impaired release of a soluble natural killer cytotoxic factor in SLE. Arthritis Rheum 1984;27:1095.
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