The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals

Li Ming-zhen; Ye Wang-yun; Tu Sheng-hao; Hou An-ji; Deng Ze-ming; Lu Fu-er; Wang Kai-fu; Lin Bao-ying

doi:10.1007/BF02942941

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The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals

Updated：2021-08-27

- The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals
- Chinese Journal of Integrative Medicine Vol. 1, Issue 3, Pages: 223-226(1995)
- Affiliations：
  
  Institute of Integrated Traditional Chinese Medicine and Western Medicine, Tongji Medical University,Wuhan
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- DOI：10.1007/BF02942941
  CLC：
- Published：1995，
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Li, Mz., Ye, Wy., Tu, Sh. et al. The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals., CJIM 1, 223–226 (1995). https://doi.org/10.1007/BF02942941

Li Ming-zhen, Ye Wang-yun, Tu Sheng-hao, et al. The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals. [J]. Chinese Journal of Integrative Medicine 1(3):223-226(1995)
Li, Mz., Ye, Wy., Tu, Sh. et al. The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals., CJIM 1, 223–226 (1995). https://doi.org/10.1007/BF02942941 DOI：

Li Ming-zhen, Ye Wang-yun, Tu Sheng-hao, et al. The preventive-therapeutic effects of reduqing (热毒清) on endotoxin-induced DIC in rabbits (Continued) protection of hepatocytic microsomes, maintenance of calcium homeostasis and reduction of oxygen free radicals. [J]. Chinese Journal of Integrative Medicine 1(3):223-226(1995) DOI： 10.1007/BF02942941.

摘要

Disseminated intravascular coagulation (DIC) model of rabbits was made by the injection of endotoxin. Cytochrome P-450 content and aniline hydroxylase activity in hepatocytic microsomes in DIC rabbits were significantly reduced. The microviscosity of mitochondrial membrane was elevated

while the fluidity of the membrane

and the activities of calcium-magnesium-adenosine triphosphatase and calcium-adenosine triphosphatase were reduced. Lipid peroxide and xanthine oxidase activities were increased

while superoxide dismutase and glutathione peroxidase activities were significantly decreased (P<0.05 or <0.01). The changes in the Reduqing test group were not prominent

and the parameters of the test group were close to those of the control group. This study suggests that in endotoxin induced DIC rabbits the hepatocytic microsomes are injured

calcium homeostasis is disturbed and oxygen free radicals are notably accumulated. Whereas Reduqing may have a protective effect on hepatocytic microsomes from the injury

maintain calcium homeostasis and reduce oxygen free radicals in DIC rabbits.

Abstract

while the fluidity of the membrane

and the activities of calcium-magnesium-adenosine triphosphatase and calcium-adenosine triphosphatase were reduced. Lipid peroxide and xanthine oxidase activities were increased

while superoxide dismutase and glutathione peroxidase activities were significantly decreased (P<0.05 or <0.01). The changes in the Reduqing test group were not prominent

and the parameters of the test group were close to those of the control group. This study suggests that in endotoxin induced DIC rabbits the hepatocytic microsomes are injured

calcium homeostasis is disturbed and oxygen free radicals are notably accumulated. Whereas Reduqing may have a protective effect on hepatocytic microsomes from the injury

maintain calcium homeostasis and reduce oxygen free radicals in DIC rabbits.

关键词

Reduqingendotoxinmicrosomecalcium homeostasisoxygen free radicals

Keywords

Reduqingendotoxinmicrosomecalcium homeostasisoxygen free radicals

references

Lin Ju-sheng, et al. Inhibitory action in Chinese medical preparation — anti-inflammation agent No. 6 — on DIC resulting from endotoxin: Experimental study. Acta Academiae Medicinae Wuhan 1985;5(1):23.

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Estabrook RW, et al. Methods in pharmacology. Vol. 12. New York: Appecton-Centurycrofts, 1972:303–305.

O’Brien PJ, et al. A peroxidase assay for cytochrome P-450. In: Fleischer S. Methods in Enzymology. Vol. 1. New York: Academic Press Inc, 1978:407–409.

1988; 14(5):300.

Reinila M, et al. Standardized methods for the determination of human erythrocyte membrane adenosine triphosphatase. Anal Biol Chem 1982; 124:19.

Ohkawa H, et al. Assay for lipid peroxides in animal tissues by thiobituric acid reaction. Anal Biochem 1979; 95(2):351.

1987; 7(2):47.

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1986; (5):65.

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Fundamental Medical Sciences Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Department of Pharmacology, Tianjin Medical University

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Institution of Integration of Traditional Chinese and Western Medicine, Tongji Medical University

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