Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats

Song Lu-cheng; Chen Ke-zhong; Zhu Jia-yan

doi:10.1007/BF02947293

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Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats

Updated：2021-08-27

- Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats
- Chinese Journal of Integrative Medicine Vol. 1, Issue 1, Pages: 59-62(1995)
- Affiliations：
  
  1. Shandong Qianfe-shan Hospital,Jinan
  2. Affiliated Hospital of Shandong Medical University,Jinan
- Author bio：
- Funds：
- DOI：10.1007/BF02947293
  CLC：
- Published：1995，
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Song, Lc., Chen, Kz. & Zhu, Jy. Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats., CJIM 1, 59 (1995). https://doi.org/10.1007/BF02947293

Song Lu-cheng, Chen Ke-zhong, Zhu Jia-yan. Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats. [J]. Chinese Journal of Integrative Medicine 1(1):59-62(1995)
Song, Lc., Chen, Kz. & Zhu, Jy. Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats., CJIM 1, 59 (1995). https://doi.org/10.1007/BF02947293 DOI：

Song Lu-cheng, Chen Ke-zhong, Zhu Jia-yan. Effects ofCoptis chinensis on lipid peroxidation and antioxidases activity of rats. [J]. Chinese Journal of Integrative Medicine 1(1):59-62(1995) DOI： 10.1007/BF02947293.

摘要

Coptis chinensis and the brain homogenate of rat were mixed and incubated to investigate the effects of Coptis on lipid peroxidation. The results showed that the malondialdehyde product of rat brain homogenate inhibited by 5% Coptis was significantly different from that of the control group (P<0.001). On the basis of the above-mentioned results

the effect of Coptis on lipid peroxidation and diabetes in rats induced by alloxan was investigated. The results showed: (1) The malondialdehyde product of both the pancreas and liver homogenate in the Coptis (test) group was significantly less than that in blank control and the alloxan (control) group (P<0.01

P<0.05). (2) Superoxide dismutases in erythrocytes activity was the same for all groups (P>0.50). (3) The blood catalase activity in the control group markedly decreased compared with the blank control group (P<0.05)

but no significant change between the test and control group (P>0.05) occurred. (4) The value of serum glucose in the control group was significantly increased compared with the blank control group (P<0.05). A decrease in the value of serum glucose in the test group compared with the control group occurred

but with no significant difference between the two groups (P>0.05).

Abstract

but with no significant difference between the two groups (P>0.05).

关键词

Coptis chinensismalondialdehydesuperoxide dismutasecatalase

Keywords

Coptis chinensismalondialdehydesuperoxide dismutasecatalase

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Sakurai K, et al. Iron release from ferritin and generation of hydroxyl radical in the reaction system of alloxan with reduced glutathione: a role of ferritin in alloxan toxicity. Chem Pharm Bull 1988;36(11):4534.

Fridovich I. Superoxide radical: an endogenous toxicant. Ann Rev Pharmacol Toxicol 1983;23:23.

Jain SK, et al. Erythrocyte membrane lipid peroxidation and glycosylated hemoglobin in diabetes. Diabetes 1989;38:539.

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Renji Hospital Affiliated to Shanghai Second Medical University

Shandong University of Traditional Chinese Medicine

Shandong Medical Univeristy

Institute of Materia Medica, Chinese Academy of Medical Sciences

Beijing Hospital, National Center for Clinical Laboratories

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