Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell

Yanmei Li; Zhong Wang; Jin Weng; Zhiyong Chen; Keji Chen

doi:10.1007/BF02947371

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Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell

Updated：2021-08-27

- Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell
- Chinese Journal of Integrative Medicine Vol. 6, Issue 4, Pages: 254-257(2000)
- Affiliations：
  
  1. China Academy of TCM, Xiyuan Hospital,Beijing
  2. Institute of Basic Medicine, PUMC, Academy of Chinese Medical Sciences,China
- Author bio：
- Funds：
- DOI：10.1007/BF02947371
  CLC：
- Published：2000，
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Li, Y., Wang, Z., Weng, J. et al. Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell., CJIM 6, 254–257 (2000). https://doi.org/10.1007/BF02947371

Yanmei Li, Zhong Wang, Jin Weng, et al. Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell. [J]. Chinese Journal of Integrative Medicine 6(4):254-257(2000)
Li, Y., Wang, Z., Weng, J. et al. Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell., CJIM 6, 254–257 (2000). https://doi.org/10.1007/BF02947371 DOI：

Yanmei Li, Zhong Wang, Jin Weng, et al. Effect of xuefu zhuyu decoction on the function of platelets and human umbilical vein endothelial cell. [J]. Chinese Journal of Integrative Medicine 6(4):254-257(2000) DOI： 10.1007/BF02947371.

摘要

Objective: To explore the effect of Xuefu Zhuyu Decoction (XZD) on molecular expression of platelets glycoprotein II b/III a complex (GP II b/III a) and thrombomodulin (TM) of human umbilical vein endothelial cells.Methods: Platelets and human umbilical vein endothelial cells were incubated with XZD of different concentration. GP II b/III a and TM were evaluated by radioimmunoassay.Results: XZD in 40 mg/ml and 80 mg/ml could obviously inhibit the adenosine diphosphate induced GII b/III a complex expression

the molecular number being 52900 ± 8445 and 52095 ± 6345 respectively

and there was significant difference as comparing with that in the control group ( P < 0.05

P<0.01). But XZD didn’t show any influence on the molecular expression of TM in human umbilical vein endothelial cells.Conclusion: XZD could inhibit the adenosine diphosphate induced activation of platete through blocking the exposure of GII b/III a a complex.

Abstract

the molecular number being 52900 ± 8445 and 52095 ± 6345 respectively

and there was significant difference as comparing with that in the control group ( P < 0.05

关键词

platelet glycoprotein II b/III a complexthrombomodulin (TM)kw]human umbilical vein endothelial cell

Keywords

platelet glycoprotein II b/III a complexthrombomodulin (TM)kw]human umbilical vein endothelial cell

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