Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine

Jianhua Wang; Zaiji Yu; Aihua Zhang; Haiyan Hao

doi:10.1007/BF02947376

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Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine

Updated：2021-08-27

- Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine
- Chinese Journal of Integrative Medicine Vol. 6, Issue 4, Pages: 266-270(2000)
- Affiliations：
  
  1. Institute of Activating Blood Circulation to Removing Stasis, Gynecopathy of Shanxi Province,Taiyuan
  2. Hospital of Maternal and Child Health Care of Shanxi Province,China
- Author bio：
- Funds：
- DOI：10.1007/BF02947376
  CLC：
- Published：2000，
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Jianhua, W., Zaiji, Y., Aihua, Z. et al. Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine., CJIM 6, 266–270 (2000). https://doi.org/10.1007/BF02947376

Jianhua Wang, Zaiji Yu, Aihua Zhang, et al. Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine. [J]. Chinese Journal of Integrative Medicine 6(4):266-270(2000)
Jianhua, W., Zaiji, Y., Aihua, Z. et al. Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine., CJIM 6, 266–270 (2000). https://doi.org/10.1007/BF02947376 DOI：

Jianhua Wang, Zaiji Yu, Aihua Zhang, et al. Clinical study of ectopic pregnancy treated with integrated traditional chinese and western medicine. [J]. Chinese Journal of Integrative Medicine 6(4):266-270(2000) DOI： 10.1007/BF02947376.

摘要

Objective: To explore the therapeutic effect and mechanism of integrated traditional Chinese and western medicine (TCM-WM) in treating ectopic pregnancy (EP).Methods: Seventy-eight patients suffering from unruptured EP were divided into two groups at random in proportion of roughly 2:1

Group I (n= 50) was treated with methotrexate (MTX) plus Ectopic Pregnancy No. 2 (EP2)

a Chinese medicinal decoction

Group II (n=28) was treated with MTX alone for control.Results:In Group I

the nonsurgical cure rate

involving side tubal patency rate and intrauterine pregnancy rate

were 98. 0%

88. 0% and 80. 0% respectively

the three parameters were all higher than those in Group II (75. 0%

46. 4% and 42. 9% respectively). Moreover

the EP recurrence rate in Group I was lower than that in Group II (4.0% vs l4.2%)

the serum β-hCG normalizing time and total disappearance time of EP mass in Group I (25.0 ± 7. 8 days and 1.2 ± 0.7 months) were shorter than those in Group II (31.9 ± 6.7 days and 5.6 + 3.7 months)

also showing significant difference (P<0. 05 and P<0. 01 respectively). After being treated by EP2 decoction for 4–8 weeks

the hemorrheological parameters in Group I were improved more markedly than those in Group II.Conclusion: The TCM-WM treatment (MTX plus EP2) could effectively increase nonsurgical cure rate

tubal patency rate and intrauterine pregnancy rate

decrease EP recurrence rate

and reduce the serum β-hCG normalizing time and the total disappearance time of EP mass in treating EP.

Abstract

Group I (n= 50) was treated with methotrexate (MTX) plus Ectopic Pregnancy No. 2 (EP2)

a Chinese medicinal decoction

Group II (n=28) was treated with MTX alone for control.Results:In Group I

the nonsurgical cure rate

involving side tubal patency rate and intrauterine pregnancy rate

were 98. 0%

88. 0% and 80. 0% respectively

the three parameters were all higher than those in Group II (75. 0%

46. 4% and 42. 9% respectively). Moreover

the EP recurrence rate in Group I was lower than that in Group II (4.0% vs l4.2%)

also showing significant difference (P<0. 05 and P<0. 01 respectively). After being treated by EP2 decoction for 4–8 weeks

the hemorrheological parameters in Group I were improved more markedly than those in Group II.Conclusion: The TCM-WM treatment (MTX plus EP2) could effectively increase nonsurgical cure rate

tubal patency rate and intrauterine pregnancy rate

decrease EP recurrence rate

and reduce the serum β-hCG normalizing time and the total disappearance time of EP mass in treating EP.

关键词

ectopic pregnancyEctopic Pregnancy No. 2methotrexate

Keywords

ectopic pregnancyEctopic Pregnancy No. 2methotrexate

references

Cacciatore B, Stenman UH, Yiöstalo P. Comparison of abdominal and vaginal sonography in suspected ectopic pregnancy. Obstet Gynecol 1989; 73:770–774.

Fernandez H, Benifla JL, Lelaidier C, et al. Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control. Fertil Steril 1993:59:773–777.

Stovall TG, Ling FW. Single-dose methotrexate: An expanded clinical trial. Am J Obstet Gynecol 1993; 168(6): 1759–1765.

Research Group of Treatment of Extrauterine Pregnancy by TCM-WM. Experimental study on treatment of extrauterine pregnancy by integrated traditional Chinese and western medicine. Chin J Obst & Gyn 1979, 14:279–282.

Wang JH, Yu ZJ. Combination of single-dose methotrexate and Chinese medicinal herbs for treating ectopic pregnancy. Chin Med J 1998;lll(ll):1047.

Liu Zhufeng, Lang Jinghe, HUANG Rongli, et al. Treatment of extrauterine pregnancy by single intramuscular injection of amethopterin. Chin J Obst & Gyn 1996, 31(8): 490–492.

Petra J, Ben WJ, Ralph R, et al. Serum human chorionic gonadotropin clearance curves in patients with interstitial pregnancy treated with systemic methotrexate. Fertil Steril 1996:66(5):723–728.

Yu Zaiji. Experimental study on Chinese recipe for treatment of extrauterine pregnancy. In: SONG Hongzhao, GAO Yaojie edit. Practical gynecotokology. 1st edition. Zhengzhou: Henan Sciences and Technology Press 1990:244 -246.

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Related Institution

Institute of Activating Blood Circulation to Remove Stasis, Gynecopathy of Shanxi Province

Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine

Department of Obstetrics & Gynecology, Hospital affiliated to Shandong University of Traditional Chinese Medicine, Ji’nan

Laboratory of Reproductive Immunology, Institute of Obstetrics & Gynecology, Fudan University

Affiliated Xinhua Hospital, Shanghai Second Medical University

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