Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

Hao Xu; Dazhuo Shi; Keji Chen; Xiaochang Ma; Yongli Li; Liang Meng; Weimin Yuan

doi:10.1007/BF02947380

Your Location：

Home >

Browse articles >

Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model

Updated：2021-08-27

- Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model
- Chinese Journal of Integrative Medicine Vol. 6, Issue 4, Pages: 278-282(2000)
- Affiliations：
  
  1. Division of Cardiovascular Diseases, Xiyuan Hospital, China Academy of TCM,Beijing
  2. Department of Experimental Surgery, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences,China
- Author bio：
- Funds：
  
  Part of a National Ninth-Five Planning Project (No. 96-9060601)
- DOI：10.1007/BF02947380
  CLC：
- Published：2000，
Scan for full text
Xu, H., Shi, D., Chen, K. et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model., CJIM 6, 278–282 (2000). https://doi.org/10.1007/BF02947380

Hao Xu, Dazhuo Shi, Keji Chen, et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model. [J]. Chinese Journal of Integrative Medicine 6(4):278-282(2000)
Xu, H., Shi, D., Chen, K. et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model., CJIM 6, 278–282 (2000). https://doi.org/10.1007/BF02947380 DOI：

Hao Xu, Dazhuo Shi, Keji Chen, et al. Effect of xiongshao capsule on vascular remodeling in porcine coronary balloon injury model. [J]. Chinese Journal of Integrative Medicine 6(4):278-282(2000) DOI： 10.1007/BF02947380.

摘要

Objective: To study the effect of Xiongshao capsule (XSC) on vascular remodeling in porcine coronary balloon injury model.Methods: Coronary artery restenosis model was established by oversized balloon injury at mid-region of the left anterior descending coronary artery. They were divided into 5 groups

untreated or treated with probucol

Xueguantong

low and high dose of XSC respectively

and compared. The effect of XSC on late lumen loss resulted from vascular remodeling was evaluated by quantitative histological method with combining histopathological analysis and coronary angiographie examination.Results: The (59 ± 20)% of late lumen loss was caused by vascular remodeling and (41 ± 20)% caused by intimai hyperplasia. Compared with the control group

all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 )

both low and high dose of XSC could significantly reduce the late lumen loss caused by remodeling (P<0.05 and P<0.01 respectively).Conclusion: Vascular remodeling plays an important role in late lumen stenosis formation in coronary artery after balloon injury. XSC could significantly inhibit the pathological vascular remodeling

and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.

Abstract

untreated or treated with probucol

Xueguantong

low and high dose of XSC respectively

all the treatment could significantly reduce the late lumen loss after balloon injury (P<0.05 orP < 0.01 )

and thus reduce the late lumen loss and prevent the restenosis of the injured coronary artery.

关键词

Xiongshao capsuleangioplastyrestenosisvascular remodeling

Keywords

Xiongshao capsuleangioplastyrestenosisvascular remodeling

references

Hong MK, Mehran R, Mintz GS, et al. Restenosis after coronary angioplasty. Current Problems in Cardiology 1997;22:5–36.

Shi DZ, Xu FQ, Li LZ. The experimental study of Xueguantong on preventing restenosis after percutaneous transluminal angioplasty. CJIM(Eng)1995; 1(4): 284–287.

Shi DZ, Li J, Ma XC. Clinical observation on preventing restenosis after PTCA treated with Concentrated Xuefu Zhuyu Pill. J Traditional Chin Med 1997;38:27–29.

Schneider JE, Berk BC, Gravanis MB, et al. Probucol decrease neointimal formation in a swine model of coronary artery balloon injury: a possible role for antioxidants in restenosis. Circulation 1993;88:628–637.

Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimai hyperplasia in lumen renarrowing after balloon angioplasty: a study in the normal rabbit and the hypercholesterolemic Yucatan micropig. Circulation 1994;89:2816–2821.

Lafont A, Guzman LA, Whitlow PL, et al. Restenosis after experimental angioplasty. Intimai, medial, and adventitial changes associated with constrictive remodeling. Circ Res 1995; 76:996–1002.

Kovach JA, Mintz GS, Kent KM, et al. Serial intravascular ultrasound studies indicate that chronic recoil is an important mechanism of restenosis following transcatheter therapy [abstract]. J Am Coll Cardiol 1993;21(suppl A): 484A.

Mintz GS, Kovach JA, Saturmino PJ, et al. Geometric remodeling is the predominant mechanisms of late lumen loss after coronary angioplasty [abstract]. Circulation 1993; 88:(suppl I): 1–654.

Wiegman PJ, Barry WL, Mcpherson JA, et al. All-transretinoic acid limits restenosis after balloon angioplasty in the focally atherosclerotic rabbit: a favorable effect on vessel remodeling. Arterioscler Thromb Vasc Biol 2000; 20 : 89–95.

Cote G, Tardif JC, Lesperance J, etal. Effects of probucol on vascular remodeling after coronary angioplasty. Mul- tivitamins and Probucol Study Group. Circulation 1999; 99:30–35.

Sabate M, Serruys PW, van der Giessen WJ, et al. Geometric vascular remodeling after balloon angioplasty and β- radiation therapy: A three-dimensional intravascular ultrasound study. Circulation 1999; 100:1182–1188.

FULL TEXT LINK

More>

Views

378

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Clinical study of xiongshao capsule in preventing restenosis after coronary interventional treatment

A multi-center randomized double-blind placebo-controlled trial of Xiongshao Capsule (芎芍胶囊) in preventing restenosis after percutaneous coronary intervention: A subgroup analysis of senile patients

Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery

Combined common femoral artery endarterectomy with superficial femoral artery stenting plus Shuxuening Injection (舒血宁注射液) infusion for chronic lower extremity ischemia: 3-year results

Xiongshao Capsule (芎芍胶囊) promotes angiogenesis of HUVEC via enhancing cell proliferation and up-regulating the expression of bFGF and VEGF

Related Author

No data

Related Institution

Xiyuan Hospital, China Academy of TCM

The Third Hospital Affiliated to Peking University, Health Science Center

Anzhen Hospital Affiliated to Capital University of Medical Sciences

Xiyuan Hospital, China Academy of Chinese Medical Sciences

National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰