Objective: To observe the effect of Zhenjian Granule (ZJG) in improving essential hypertension and insulin resistance (IR).Methods: The 52 patients of hypertension were randomly divided into the ZJG group (n=32) and the control group (n=20)

treated with ZJG and captopril respectively for 4 weeks. The changes of blood pressure

glucose

insulin

insulin sensitivity index (ISI) and blood lipid in them before and after treatment were determined and compared with those in normal group (17 healthy subjects).Results: Fasting insulin

blood glucose

and insulin 2 hrs after meal in hypertension patients before treatment were significantly higher but ISI was significantly lower than those in the normal control

indicating the existence of insulin resistance. After treatment

not only blood pressure in patients obviously lowered

but also levels of fasting insulin

blood glucose

and insulin 2 hrs after meal obviously lowered

while ISI markedly raised. IR was improved in both groups

and blood lipid were also improved in the ZJG group.Conclusion: ZJG was effective in reducing blood pressure

also it had significant effect in improving metabolic disorder

particularly on IR in patients of essential hypertension.