Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats

Xiangrong Rao; Shen Li; Xiwen Dai; Jun Li

doi:10.1007/BF02947386

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Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats

Updated：2021-08-27

- Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats
- Chinese Journal of Integrative Medicine Vol. 6, Issue 4, Pages: 295-298(2000)
- Affiliations：
  
  Guang’anmen Hospital, China Academy of Traditional Chinese Medicine,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02947386
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- Published：2000，
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Rao, X., Li, S., Dai, X. et al. Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats., CJIM 6, 295–298 (2000). https://doi.org/10.1007/BF02947386

Xiangrong Rao, Shen Li, Xiwen Dai, et al. Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats. [J]. Chinese Journal of Integrative Medicine 6(4):295-298(2000)
Rao, X., Li, S., Dai, X. et al. Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats., CJIM 6, 295–298 (2000). https://doi.org/10.1007/BF02947386 DOI：

Xiangrong Rao, Shen Li, Xiwen Dai, et al. Effect of huan-shuai recipe on expression of extracellular matrix in 5/6 nephrectomized rats. [J]. Chinese Journal of Integrative Medicine 6(4):295-298(2000) DOI： 10.1007/BF02947386.

摘要

Objective: To investigate the effect of Huan-shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor-β2 (TGF-β2) in the remnant kidney of rats.Methods : Male Wistar rats

after 4 weeks of 5/6 nephrectomy

were divided into two groups at random

and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24-hours were observed at beginning

6th week and 12th week of the experiment

and FN and TGF-β2 were assayed by immunohistochemical technique and computer assisted image analysis as well.Results : Serum SCr and urinary protein of 24-hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment

as compared with those in the control group

and the difference was significant (P < 0.05); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF-β2 in animals of the HSR group with significant difference from those in the control group (P<0.05).Conclusion : HSR not only plays the role of renal function protection

but could also alleviate the glomerular pathological injury. The effect on TGF-β2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.

Abstract

after 4 weeks of 5/6 nephrectomy

were divided into two groups at random

and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24-hours were observed at beginning

6th week and 12th week of the experiment

as compared with those in the control group

but could also alleviate the glomerular pathological injury. The effect on TGF-β2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.

关键词

Huan-shuai Recipes5/6 nephrectomized ratstransforming growth factor-β2extracellular matrix

Keywords

Huan-shuai Recipes5/6 nephrectomized ratstransforming growth factor-β2extracellular matrix

references

Yin DH, Dai XW, Rao XR. Effect of Yishen Huanshuai recipes in retarding progression of chronic renal failure. CJIM 1998:18(7):402.

Border WA, Noble NA. Transforming growth factor-β in tissue fibrosis. N Engl Med 1994; 331:1286–1292.

Border WA, Okuda S, et al. Transforming growth factor-β regulates production of proteoglycans by mesangial cells. Kidney Int 1990; 37:689.

Border WA, OkudaS, et al. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor-β2. Nature (Lond) 1990; 346:371–374.

Junaid A, Rosenberyg ME, Hosteiter TH. Interaction of angiotensin II (A II) and transforming growth factor beta (TGF-β) in the remnant Kidney (abstract). J Am Soc Nephrol 1993; 4:772–776.

Wu YG, Lin SY, YuY, et al. The expression of transforming growth factor-β2 in the renal cortex of uninephrectomized diabetic nephropathy rats. Chinese Journal of Nephrology 1998; 14(5):301.

Roth S, Schurek J, Gressner AM: Expression and release of the latent transforming growth factor beta binding protein by hepatocytes from rat liver. Hepatology 1997; 25: 1398–1405.

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Department of Biochemistry and Molecular Biology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

China Academy of Chinese Medical Sciences

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