Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ

Na Liu; Pingping Zuo; Fenghua Liu; Hongyu Xue

doi:10.1007/BF02950928

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Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ

Updated：2021-08-27

- Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ
- Chinese Journal of Integrative Medicine Vol. 6, Issue 3, Pages: 200-203(2000)
- Affiliations：
  
  Institute of Basic Medicine, Peking Union Medical College,Beijing
- Author bio：
- Funds：
  
  ΔThis program was supported by National Nature Science Foundation of China (No.39421012)
- DOI：10.1007/BF02950928
  CLC：
- Published：2000，
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Liu, N., Zuo, P., Liu, F. et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ., CJIM 6, 200–203 (2000). https://doi.org/10.1007/BF02950928

Na Liu, Pingping Zuo, Fenghua Liu, et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ. [J]. Chinese Journal of Integrative Medicine 6(3):200-203(2000)
Liu, N., Zuo, P., Liu, F. et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ., CJIM 6, 200–203 (2000). https://doi.org/10.1007/BF02950928 DOI：

Na Liu, Pingping Zuo, Fenghua Liu, et al. Study on mechanism of huanshao dan in brain protectionΔin brain protectionΔ. [J]. Chinese Journal of Integrative Medicine 6(3):200-203(2000) DOI： 10.1007/BF02950928.

摘要

Objective: To observe the behavioral and biochemical effects of a traditional Chinese medicine Huanshao Dan (HSD) on learning and memory deficits in transient cerebral ischemia model in mice.Methods: Step-through experiments

receptor binding test and choline acetyltransferase (ChAT) activities determination were performed.Results: Mice undertaken transient ischemia commited much more mistakes in step-through experiments and showed relatively higher3 H-MK801 binding in cerebral cortex and hippocampus than in sham operated animals. HSD decoction was most effective in reducing these mistakes in mice. At the same time

and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased

while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.

Abstract

and3 H-MK801 binding of cerebral cortex and hippocampus tissues were also significantly decreased

while ChAT activities in the same tissues were increased.Conclusion: HSD might antagonize ischemic injury of brain through inhibition of glutamate N-methyl-D-Aspartic acid receptor overactivity.

关键词

Huanshao Danexcitoxintransient cerebral ischemiaN-methyl-D-Aspartic acid receptorcholine acyltransferase

Keywords

Huanshao Danexcitoxintransient cerebral ischemiaN-methyl-D-Aspartic acid receptorcholine acyltransferase

references

DU X, Yan RX, Chen XQ, et al. Study of effect on anti- aging and treating Yang-Deficiency of Kidney with Huanshao Dan capsules—A clinical report of 300 cases. CJIM 1992; 12 (1):20–22.

Miyamoto M, Shintani M, Nagaoka A, et al. Lesioning of the basal forebrain leads to memory impairments in passive and active avoidance tasks. Brain Res 1985; 328:97–104.

Kiyokazu Ogita and Yukio Yoneda. Solubilization of spermi- dine-sensitive (+)-[3H] 5-methyl-10, ll-dihydro-5H-dibenzo [a,d]cyclohapten-5,10-imine([3H]MK801) binding activity from rat brain. J Neurochem 1990;55(5):1515–1520.

Nordberg A and Winblad B. Cholinergic receptors in human hippocampus-regional distribution and variance with age. Life Sci 1981; 29:1937–1944.

Fonnum F. A rapid radiochemical method for the determina- tion of choline acetyltransferase. J Neurochem 1975; 24:407–409.

Esen, Asim. A simple method for quantitative, semi-quantitative, and qualitative assay of protein. Analytical Biochem 1978;89(1):264(Eng).

William P, Abigail S and Alastair B. Antagonism of the NM- DA and non-NMDA receptors in blood versus focal brain ischemia. Pro in Brain Res 1993;96:125–135.

Bowen DM, Smith CB, White P, et al. Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other biotrophies. Brain 1976; 99:459–496.

Zuo PP, Zhang SY, Chen JJ, et al. The changes of CAT activity during the memory acquisition in rats brain. Basic and Clin Med 1997; 17(6):72.

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Department of Physiology, Tianjin University of Traditional Chinese Medicine

College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine

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Department of Traditional Chinese Medicine, Jinling Hospital, Nanjing University

Institute of Integrated Traditional and Western Medicine, Huashan Hospital Affiliated to Fudan University

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