Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats

Jian CHEN; Bing HE; Xinmin LIU; Haibin WANG; Wei ZHANG; Ying ZHANG

doi:10.1007/BF02950942

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Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats

Updated：2021-08-27

- Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats
- Chinese Journal of Integrative Medicine Vol. 6, Issue 3, Pages: 232(2000)
- Affiliations：
  
  Department of Pulmonary Medicine, The First Hospital of Beijing Medical University,Beijing
- Author bio：
- Funds：
- DOI：10.1007/BF02950942
  CLC：
- Published：2000，
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Jian, C., Bing, H., Xinmin, L. et al. Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats., CJIM 6, 232 (2000). https://doi.org/10.1007/BF02950942

Jian CHEN, Bing HE, Xinmin LIU, et al. Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats. [J]. Chinese Journal of Integrative Medicine 6(3):232(2000)
Jian, C., Bing, H., Xinmin, L. et al. Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats., CJIM 6, 232 (2000). https://doi.org/10.1007/BF02950942 DOI：

Jian CHEN, Bing HE, Xinmin LIU, et al. Experimental study on effect of folium ginkgo biloba in treating pulmonary interstitial fibrosis in rats. [J]. Chinese Journal of Integrative Medicine 6(3):232(2000) DOI： 10.1007/BF02950942.

摘要

Objective: To evaluate the therapeutic effect and mechanism of folium Ginkgo biloba (FGB) in treating pulmonary interstitial fibrosis (PIF) induced by bleomycin in rats.Methods: PIF models of bleomycin-A5-induced pulmonary fibrosis were established in rats

they were treated by Bailuda

a preparation of FGB

and the pathological changes

collagen protein level

nuclear factor kB(NF-kB) activity

transforming growth factor β (TGF-β) mRNA expression and protein level of the lung tissue were measured.Results: In the Bailuda treated group after treatment

amelioration of the pulmonary alveolitis and fibrosis were shown in pathological section (P < 0.05) and collagen protein content was lesser (P<0.01) as compared with those in the model control group. After 1 week of Bailuda treatment

the NF-kB activity of pulmonary alveola macrophage lowered by 47. 3 %

and levels of TGF-β mRNA expression and protein were all decreased (P < 0.05).Conclusions: Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB

decreasing TGF-β mRNA expression and protein

so as to ameliorate the inflammation and fibrosis.

Abstract

they were treated by Bailuda

a preparation of FGB

and the pathological changes

collagen protein level

nuclear factor kB(NF-kB) activity

transforming growth factor β (TGF-β) mRNA expression and protein level of the lung tissue were measured.Results: In the Bailuda treated group after treatment

the NF-kB activity of pulmonary alveola macrophage lowered by 47. 3 %

and levels of TGF-β mRNA expression and protein were all decreased (P < 0.05).Conclusions: Bailuda has definite effect in treating PIF. The mechanism may be through inhibiting the activity of NF-kB

decreasing TGF-β mRNA expression and protein

so as to ameliorate the inflammation and fibrosis.

关键词

BleomycinFebrile ConvulsionPathological SectionModel Control GroupTongue Coating

Keywords

BleomycinFebrile ConvulsionPathological SectionModel Control GroupTongue Coating

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Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University, Bejing

Institute of Integrated Traditional Chinese and Western Medicine, The First Hospital of Beijing Medical University

Qingdao Municipal Hospital of Traditional Chinese Medicine

Department of Respiratory Diseases, The Affiliated Hospital of Guilin Medical College

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