Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo

Yong-Pei Jiang; Ai-Dong Wen; Xi Huang; Yi-Min Zang; Lei-Hua Zhang

doi:10.1007/BF02969669

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Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo

Updated：2021-08-27

- Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo
- Chinese Journal of Integrative Medicine Vol. 2, Issue 2, Pages: 132-134(1996)
- Affiliations：
  
  1. Department of Clinical Pharmacology, Xijing Hospital, Fourth Military Medical University, Xi’rsan
  2. Department of Gastroenterological Surgery, Xijing Hospital, Xi’rsan
- Author bio：
- Funds：
- DOI：10.1007/BF02969669
  CLC：
- Published：1996，
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Jiang, YP., Wen, AD., Huang, X. et al. Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo., CJIM 2, 132–134 (1996). https://doi.org/10.1007/BF02969669

Yong-Pei Jiang, Ai-Dong Wen, Xi Huang, et al. Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo. [J]. Chinese Journal of Integrative Medicine 2(2):132-134(1996)
Jiang, YP., Wen, AD., Huang, X. et al. Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo., CJIM 2, 132–134 (1996). https://doi.org/10.1007/BF02969669 DOI：

Yong-Pei Jiang, Ai-Dong Wen, Xi Huang, et al. Pharmacokinetics of tetramethylpyrazine phosphate in healthy and blood stasis dogs in vivo. [J]. Chinese Journal of Integrative Medicine 2(2):132-134(1996) DOI： 10.1007/BF02969669.

摘要

To test the hypothesis of Syndrome and Treatment Pharmacokinetics (S-TPK)

the authors have studied the pharmacokinetics of tetramethyrazine phosphate (TMPP) in healthy and blood stasis dogs by high performance liquid chromatography. After a single intravenous injection of TMPP 8 mg kg-1 to healthy and blood stasis dogs

compartment model of TMPP serum concentration was fitted and then pharmacokinetic parameters were calculated with a Microcomputer Pharmacokinetic Program on a Compaq 80386 computer. Important parameters were as follows: in the healthy dogs

T1/2P = 30. 27 ± 6. 85 min

Kel = 0.11 ± 0. 04 min-1

AUC= 445.26±51.26 mg/L min; in the blood stasis dogs

T1/2β = 71.58β10.80 min

Kel = 0.06 β0.01 min-1

AUC = 1381.85β464.68 mg/L min. Through this experiment it was found that there was significant difference in the pharmacokinetic parameters between healthy and blood stasis dogs. The results obtained are consistent with S-TPK hypothesis.

Abstract

To test the hypothesis of Syndrome and Treatment Pharmacokinetics (S-TPK)

T1/2P = 30. 27 ± 6. 85 min

Kel = 0.11 ± 0. 04 min-1

AUC= 445.26±51.26 mg/L min; in the blood stasis dogs

T1/2β = 71.58β10.80 min

Kel = 0.06 β0.01 min-1

关键词

Traditional Chinese MedicinetetramethylpyrazineBlood Stasispharmacokineticshighperformance liquid chromatography

Keywords

Traditional Chinese MedicinetetramethylpyrazineBlood Stasispharmacokineticshighperformance liquid chromatography

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