Antioxidative effects of rubidate on ischemic myocardium in mice

Sheng-Li Yang; Fa Liu; Si-Ya A; Rui-Fen Cheng

doi:10.1007/BF02969671

Your Location：

Home >

Browse articles >

Antioxidative effects of rubidate on ischemic myocardium in mice

Updated：2021-08-27

- Antioxidative effects of rubidate on ischemic myocardium in mice
- Chinese Journal of Integrative Medicine Vol. 2, Issue 2, Pages: 139-140(1996)
- Affiliations：
  
  Department of Pharmacology, Xinjiang Medical College,Urumqi
- Author bio：
- Funds：
- DOI：10.1007/BF02969671
  CLC：
- Published：1996，
Scan for full text
Yang, SL., Liu, F., A, SY. et al. Antioxidative effects of rubidate on ischemic myocardium in mice., CJIM 2, 139 (1996). https://doi.org/10.1007/BF02969671

Sheng-Li Yang, Fa Liu, Si-Ya A, et al. Antioxidative effects of rubidate on ischemic myocardium in mice. [J]. Chinese Journal of Integrative Medicine 2(2):139-140(1996)
Yang, SL., Liu, F., A, SY. et al. Antioxidative effects of rubidate on ischemic myocardium in mice., CJIM 2, 139 (1996). https://doi.org/10.1007/BF02969671 DOI：

Sheng-Li Yang, Fa Liu, Si-Ya A, et al. Antioxidative effects of rubidate on ischemic myocardium in mice. [J]. Chinese Journal of Integrative Medicine 2(2):139-140(1996) DOI： 10.1007/BF02969671.

摘要

Rubidate is a phenolic compound. The present investigation was designed to establish whether rubidate protects the heart muscle against the deleterious effects of the oxygen free radicals produced by isoproterenol (ISO)-induced myocardial ischemia in mice. ISO treatment (30 mg kg-1 subcutaneous injection once daily for 2 days) caused widespread and severe myocardial cell damage

decreased myocardial glutathione peroxidase (GSH-Px)

superoxide dismutase (SOD) activities and increased myocardial malondialdehyde (MDA) content. Rubidate pretreatment 500 mg-kg-1

2000 mg.kg-1×7d protected GSH-Px

SOD activity in the hearts of ISO-treated mice. Rubidate 2000 mg-kg-1 diminished MDA production. However

rubidate 500 mg.kg-1 did not show such an effect. This study demonstrated that rubidate inhibited lipid peroxidation (LPO

expressed by malondialdehyde formation)

scavenged-Oz - and H2O2. It may be concluded that rubidate exhibits an antioxidative activity via scavenging free radicals.

Abstract

decreased myocardial glutathione peroxidase (GSH-Px)

superoxide dismutase (SOD) activities and increased myocardial malondialdehyde (MDA) content. Rubidate pretreatment 500 mg-kg-1

2000 mg.kg-1×7d protected GSH-Px

SOD activity in the hearts of ISO-treated mice. Rubidate 2000 mg-kg-1 diminished MDA production. However

rubidate 500 mg.kg-1 did not show such an effect. This study demonstrated that rubidate inhibited lipid peroxidation (LPO

expressed by malondialdehyde formation)

scavenged-Oz - and H2O2. It may be concluded that rubidate exhibits an antioxidative activity via scavenging free radicals.

关键词

rubidateisoproterenolmyocardial ischemia damagelipid peroxidationsuperoxide dismutaseglutathione peroxidasemalondialdehydeantioxidation

Keywords

rubidateisoproterenolmyocardial ischemia damagelipid peroxidationsuperoxide dismutaseglutathione peroxidasemalondialdehydeantioxidation

references

Hussain SJ, Jahan M, Asif M, et al. Beneficial effect of Taxus baccata, L. in experimental myocardial necrosis. Planta Medica 1977; 32: 133.

Das DK, Engelman RM, Rousou JA, et al. Pathophysiology of superoxide radical as potent mediator of reperfusion injury in pig heart. Basic Res Cardiol 1986; 81: 151.

Burton GW. Biological antioxidants. In: Hill H eds. Inorganic and organic radical: their biological and clinical relevance. Cambridge University Press, 1985: 115–128.

Ball SS, Weindruch R, Walford RL. Antioxidants and the immune response. In: Johnson HE, et al. eds. Free radicals, aging and degenerative disease. New Yoek: Alan R Liss Inc. 1986: 427–457.

Yang SI, Liu F, Hu J. Immune suppressive effect of ru-bidate. In: Xie MZ, Zhu XY, Cheng GF, et al. eds. Programme and abstracts. The Third China-Japan Joint Meeting on Pharmacology, Beijing: 1993; May.

FULL TEXT LINK

More>

Views

858

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effects of compound Salvia Injection on lipid peroxidation antioxidant enzymes activity in patients with chronic cor pulmonale

Effects of Shenshao Decoction(参芍汤) on the inflammatory response in the aorta of a rat atherosclerotic model

Study on effect and mechanism of sodium ferulate in preventing and treating ozone induced lung injury in mice

Protective effect of electroacupuncture and ischemic preconditioning on the circulatory function in pigs with ischemia/reperfusion myocardial injury

Experimental study on multi- lnfarct dementia treated with principle of yijing tishen

Related Author

No data

Related Institution

Nanjing Steel-Works Hospital

Nanjing Railway Medical College

Department of Cardiology, the Tangshan Worker’s Hospital of Hebei Medical University

Medical Research Center, Hebei United University

Department of Obstetrics, Beijing Fangshan District Maternal and Child Health Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰