Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM

Wu Weikang; Hou Can; Luo Hanchuan; Su Jianwen; Lin Shuguang; Chen Luyuan

doi:10.1007/BF02970574

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Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM

Updated：2021-08-27

- Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM
- Chinese Journal of Integrative Medicine Vol. 6, Issue 2, Pages: 104-107(2000)
- Affiliations：
  
  1. Institute for Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences,Guangzhou
  2. Guangdong Provincial Institute for Cardiovascular Diseases,China
- Author bio：
- Funds：
- DOI：10.1007/BF02970574
  CLC：
- Published：2000，
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Wu, W., Hou, C., Luo, H. et al. Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM., CJIM 6, 104–107 (2000). https://doi.org/10.1007/BF02970574

Wu Weikang, Hou Can, Luo Hanchuan, et al. Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM. [J]. Chinese Journal of Integrative Medicine 6(2):104-107(2000)
Wu, W., Hou, C., Luo, H. et al. Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM., CJIM 6, 104–107 (2000). https://doi.org/10.1007/BF02970574 DOI：

Wu Weikang, Hou Can, Luo Hanchuan, et al. Clinical study on therapeutic mechanism of Sini Decoction in treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCMin treating post-percutaneous transluminal coronary angioplasty ischemia-reperfusion injury in terms of syndrome typing of TCM. [J]. Chinese Journal of Integrative Medicine 6(2):104-107(2000) DOI： 10.1007/BF02970574.

摘要

Objective: To study the mechanism of Sini Decoction (SND) in prevention and treatment of post-percutaneous transluminal coronary angioplasty (PTCA) ischemia-reperfusion injury with different Syndrome typing of TCM.Methods: Forty patients who received PTCA were randomly divided equally into the SND group and the control group

there were 10 of Excess Syndrome (ES) and 10 of Deficiency Syndrome (DS)in each group. 25 ml SND was given daily to the SND group from 3 days before operation to the third day after operation. The blood Superoxide dismutase (SOD) activity

malondialdehyde (MDA) and nitric oxide (NO) content of patients were determined before PTCA

and 1 hr

12 hrs

24 hrs

48 hrs and 72 hrs after PTCA.Results: Before PTCA

the cases with DS were characterized by low SOD activity and high MDA content

as compared with the patients with ES

P<0.05. SND could relieve the post-PTCA deprivation of SOD activity and NO content and the elevation of MDA level in both ES and DS patients

the amplitude of elevation of SOD activity in DS patients was higher than that in ES patients (P<0.05).Conclusion: SND has antagonizing effect on post-PTCA ischemia-reperfusion injury

which is more effective in treating patients with DS.

Abstract

malondialdehyde (MDA) and nitric oxide (NO) content of patients were determined before PTCA

and 1 hr

12 hrs

24 hrs

48 hrs and 72 hrs after PTCA.Results: Before PTCA

the cases with DS were characterized by low SOD activity and high MDA content

as compared with the patients with ES

P<0.05. SND could relieve the post-PTCA deprivation of SOD activity and NO content and the elevation of MDA level in both ES and DS patients

the amplitude of elevation of SOD activity in DS patients was higher than that in ES patients (P<0.05).Conclusion: SND has antagonizing effect on post-PTCA ischemia-reperfusion injury

which is more effective in treating patients with DS.

关键词

Sini Decoctionpercutaneous transluminal coronary angioplastySyndrome typingischemiareperfusion injury

Keywords

Sini Decoctionpercutaneous transluminal coronary angioplastySyndrome typingischemiareperfusion injury

references

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Su Jianwen, Wu Weikang, Lin Shuguang, et al. Clinical study on effect of Sini Decoction in improving post-PT-CA myocardial ischemia and reperfusion induced arrhythmia. Chinese Journal of Traditional Chinese Medicine and Pharmacy 1997; 12(5): 14–16.

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Hei Weike, Li Juan. Relationship of Syndrome Differentiation of coronary heart disease and blood dismutase activity. Liaoning J of TCM 1994;21(11):483–484.

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DOI：10.1007/BF02970574

摘要

Abstract

关键词

Keywords

references