Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction

Wu Yusheng; Jiang Liping

doi:10.1007/BF02970577

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Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction

Updated：2021-08-27

- Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction
- Chinese Journal of Integrative Medicine Vol. 6, Issue 2, Pages: 112-115(2000)
- Affiliations：
  
  1. General Hospital of Jinan Military Region,Jinan
  2. Jinan Municipal Hospital of TCM,Jinan
- Author bio：
- Funds：
- DOI：10.1007/BF02970577
  CLC：
- Published：2000，
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Wu, Y., Jiang, L. Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction., CJIM 6, 112–115 (2000). https://doi.org/10.1007/BF02970577

Wu Yusheng, Jiang Liping. Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction. [J]. Chinese Journal of Integrative Medicine 6(2):112-115(2000)
Wu, Y., Jiang, L. Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction., CJIM 6, 112–115 (2000). https://doi.org/10.1007/BF02970577 DOI：

Wu Yusheng, Jiang Liping. Clinical study on influence of Buyang Huanwu Decoction on the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarctionon the metabolic imbalance of endothelin and calcitonin gene related peptide in patients with early cerebral infarction. [J]. Chinese Journal of Integrative Medicine 6(2):112-115(2000) DOI： 10.1007/BF02970577.

摘要

Objective: To explore the mechanism of Buyang Huanwu Decoction (BHD) in treating early cerebral infarction.Methods: Seventy cases with early cerebral infarction were randomly divided into two groups. Chinese medicine group (CMG

n = 35) was treated with BHD; western medicine group (WMG

n = 35) was treated with hydroxyethyl starch injection and enteric coated aspirin tablets. The levels of endothelin (ET) and calcitonin gene related peptide (CGRP) in plasma before and after treatment and the results of clinical treatment were observed. Also healthy subjects were used as the normal control.Results: The levels of ET before treatment in the two treated groups were significantly higher than that of the healthy subjects (P<0. 001)

and the levels of CGRP were significantly lower (P < 0.001). After treatment the metabolic imbalance of ET and CGRP improved significantly in the two treated groups (P<0. 001)

but the ET and CGRP in CMG improved more obviously than those in WMG (P<0.01

P<0.05). The markedly effective and curative rate of CMG was higher than that of WMG (68. 6 % vs 31.4 %; ϰ2 = 9. 65

P < 0. 01).Conclusion: BHD could improve the metabolic imbalance of ET and CGRP in patients with early cerebral infarction and on the virtue of this mechanism it could be used to treat cerebral infarction.

Abstract

n = 35) was treated with BHD; western medicine group (WMG

and the levels of CGRP were significantly lower (P < 0.001). After treatment the metabolic imbalance of ET and CGRP improved significantly in the two treated groups (P<0. 001)

but the ET and CGRP in CMG improved more obviously than those in WMG (P<0.01

P<0.05). The markedly effective and curative rate of CMG was higher than that of WMG (68. 6 % vs 31.4 %; ϰ2 = 9. 65

关键词

Buyang Huanwu DecoctionCerebral Infarctionendothelincalcitonin gene related peptidemetabolic imbalance

Keywords

Buyang Huanwu DecoctionCerebral Infarctionendothelincalcitonin gene related peptidemetabolic imbalance

references

Huang Youqi edited. Neurology. 2nd edition. Beijing: The People’ s Publishing House of Health, 1990: 147–155.

Zhang Boyu edited. Internal medicine of traditional Chinese medicine. Shanghai: Shanghai Publishing House of Sciences and Technology, 1985:208–214.

Wang Liheng, Gao Yongli, Mu Naizhou edited. Diagnostic and treatment standard of diseases and syndromes in traditional Chinese medicine. Jinan: Yellow River Publishing House, 1990:50–54.

Shen Jun, Chen Man’e, Shen Jiping, et al. Study on strain effect of CGRP and ET activity and the relationship between them and acute cerebral apoplexy. Journal of Apoplexy and Neuropathy, 1997; 14(3): 138–140.

Wu Yonghong, Yang Chunlu. Measurement of plasma ET content in acute apoplexy patients. Journal of Brain and Neuropathy, 1997;5(3): 152–153.

Zhang Daojie, Wu Yusheng, Peng Liyi, et al. Study on change of SOD and MDA in early stage of ischemic apoplexy treated with Buyang Huanwu Decoction. Pharmacology and Clinical Use of Traditional Chinese Drugs, 1995;ll(6):48–49.

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The Affiliated Hospital of Shandong University of TCM

Center for Evidence-Based Medicine, Xuanwu Hospital, affiliated to Capital Medical University

Department of Neurology, Xuanwu Hospital affiliated to Capital Medical University

Key Laboratory of Neurodegenerative Diseases, Capital Medical University, Ministry of Education

Cerebrovascular Diseases Research Institute, Xuanwu Hospital, affiliated to Capital Medical University

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