Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children

Lin Guozhen; Liu Dongmei; Zhu Lin; Qiu Dingzhong

doi:10.1007/BF02970579

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Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children

Updated：2021-08-27

- Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children
- Chinese Journal of Integrative Medicine Vol. 6, Issue 2, Pages: 116-118(2000)
- Affiliations：
  
  Affiliated Ruijin Hospital of Shanghai Second Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02970579
  CLC：
- Published：2000，
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Lin, G., Liu, D., Zhu, L. et al. Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children., CJIM 6, 116–118 (2000). https://doi.org/10.1007/BF02970579

Lin Guozhen, Liu Dongmei, Zhu Lin, et al. Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children. [J]. Chinese Journal of Integrative Medicine 6(2):116-118(2000)
Lin, G., Liu, D., Zhu, L. et al. Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children., CJIM 6, 116–118 (2000). https://doi.org/10.1007/BF02970579 DOI：

Lin Guozhen, Liu Dongmei, Zhu Lin, et al. Clinical Observation on Shuanghuanglian powder in treating viral myocarditis of childrenin treating viral myocarditis of children. [J]. Chinese Journal of Integrative Medicine 6(2):116-118(2000) DOI： 10.1007/BF02970579.

摘要

Objective: To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP) by injection.Methods: The 62 patients of viral myocarditis were divided into two groups randomly

the SHLP group (n = 32) treated with conventional therapy plus SHLP and the conventional treatment group (n = 30) with conventional therapy alone. Their serum antibody of Coxsackie virus group B (COXB-IgM)

T-lymphocyte subsets including CD3 +

CD4 +

CD8 + and CD4 +/CD8 + were determined with ELISA and indirect immunofluorescent assay.Results: COXB-IgM was positive in 39 of the 62 patients

which was significantly different with those of normal controls (P< 0.001). Patients’ serum level of CD4 + cells and CD4 +/CD8 + ratio decreased while CD8 + increased. After treatment

the recovery of symptoms

signs and immune function in patients of the SHLP group were significantly better than those in patients treated with conventional treatment alone (P<0.01).Conclusion: Immunoregulatory disturbance is involved in children with viral myocarditis and SHLP is an effective drug in the treatment of children viral myocarditis.

Abstract

T-lymphocyte subsets including CD3 +

CD4 +

CD8 + and CD4 +/CD8 + were determined with ELISA and indirect immunofluorescent assay.Results: COXB-IgM was positive in 39 of the 62 patients

which was significantly different with those of normal controls (P< 0.001). Patients’ serum level of CD4 + cells and CD4 +/CD8 + ratio decreased while CD8 + increased. After treatment

the recovery of symptoms

关键词

Shuanghuanglian Powderinfantile viral myocarditisT-lymphocyte subsetCoxsackievirus group B antibody

Keywords

Shuanghuanglian Powderinfantile viral myocarditisT-lymphocyte subsetCoxsackievirus group B antibody

references

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Schulze K, Schutheirs HP, Bolte HD, et al. Antibodies to ADP-ATP carrier — an autoantigen in myocarditis and dilated cardiomyopathy-impair cardiac function. Circulation 1990;81(3):959–961.

Guthrie M, Lodge PA, Huber SA. Cardiac injury in myocarditis induced by Coxsackie virus group B type 3. Cell Immunol 1984; 88:558–559.

Sun Yiping, Li Yufeng, Sun Xianping, et al. Observation on detecting of Coxsackievirus B antibody, T-lymphocyte subsets and erythrocyte immune in viral myocarditis. Clin J Pediatricsell. 1997; 15(3): 174–175.

Gao Haiquan. Pharmacology actions of drugs for clearing Heat and detoxication. Research on Chinese Patent Drugs. 1981;7:27–28.

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