Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats

Sun Fei; Yu Jin

doi:10.1007/BF02970584

Your Location：

Home >

Browse articles >

Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats

Updated：2021-08-27

- Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats
- Chinese Journal of Integrative Medicine Vol. 6, Issue 2, Pages: 127-130(2000)
- Affiliations：
  
  Obstetric and Gynecologic Hospital, Shanghai Medical University,Shanghai
- Author bio：
- Funds：
- DOI：10.1007/BF02970584
  CLC：
- Published：2000，
Scan for full text
Sun, F., Yu, J. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats., CJIM 6, 127–130 (2000). https://doi.org/10.1007/BF02970584

Sun Fei, Yu Jin. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats. [J]. Chinese Journal of Integrative Medicine 6(2):127-130(2000)
Sun, F., Yu, J. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats., CJIM 6, 127–130 (2000). https://doi.org/10.1007/BF02970584 DOI：

Sun Fei, Yu Jin. Effect of Tiangui recipe on serum leptin and pituitary gonadotropin in androgen-sterilized ratson serum leptin and pituitary gonadotropin in androgen-sterilized rats. [J]. Chinese Journal of Integrative Medicine 6(2):127-130(2000) DOI： 10.1007/BF02970584.

摘要

Objective: To explore the effect of Tiangui Recipe (TGR) on obesity and reproductive function in androgen-sterilized rats (ASR).Methods: ASR model was established by subcutaneous injection of testosterone propionate to SD female rats at the age of 9 days. Change of serum leptin

follicular stimulating hormone (FSH) and luteinizing hormone (LH) in model rats aged 115 days before and after feeding them with TGR was measured by radioimmunoassay (RIA). Meanwhile

criteria of energy state

including diurnal food intake

retroperitoneal fat depot weight and body weight

were measured and evaluated.Results: ASR had the characteristics of high metabolic rate

energy imbalance and obesity. Serum level of leptin increased and FSH

LH decreased significantly (P<0.01) in model rats as compared with the normal rats. Significant positive correlation between leptin level and body weight (r=0.8977

P<0.001) was observed

and negative correlation was seen between FSH

LH and leptin (r = -0.7517

P<0.001; r= -0.8444

P<0.001

respectively). The endocrine changes of ASR all returned to normal range after the TGR treatment.Conclusion: Obesity and concerned hypogonadotrophic hypogonadal anovulation were expressed in ASR. TGR may play an important role in reducing weight and inducing ovulation.

Abstract

follicular stimulating hormone (FSH) and luteinizing hormone (LH) in model rats aged 115 days before and after feeding them with TGR was measured by radioimmunoassay (RIA). Meanwhile

criteria of energy state

including diurnal food intake

retroperitoneal fat depot weight and body weight

were measured and evaluated.Results: ASR had the characteristics of high metabolic rate

energy imbalance and obesity. Serum level of leptin increased and FSH

LH decreased significantly (P<0.01) in model rats as compared with the normal rats. Significant positive correlation between leptin level and body weight (r=0.8977

P<0.001) was observed

and negative correlation was seen between FSH

LH and leptin (r = -0.7517

P<0.001; r= -0.8444

P<0.001

关键词

Tiangui Recipeandrogen-sterilized ratleptinPituitary Gonadotropin

Keywords

Tiangui Recipeandrogen-sterilized ratleptinPituitary Gonadotropin

references

Stewart D. Reproductive functions in eating disorders. Ann Med 1992;24:287- 291.

White BD, Martin RJ. Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide Y and leptin. Proc Soc Exp Bio Med 1997; 214:222–232.

Zhang Y, Proencea R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425–432.

Yu Jin, YANG Shuping, ZHANG Yueping, et al. Androgen induced hyperinsulinemia hyperleydigism anovulation model of rat. J Reprod Med 1993;2(4):251–259.

Zhang Yueping, YU Jin, GUI Suiqi. Pathogenesis of androgen sterilized rats and ovulation enhancing effect of Chinese herbal medicine for replenishing Kidney on it. Chin J Endocrinology and Metabolism 1994;10(2):98–101.

Gui Suiqi, YU Jin, WEI Meijuan, et al. Experimental study on effect of tonifying Kidney herbs in pituitary, ovary adrenal gland of androgen sterilized rat. CJIM 1997; 17 (12):735–738.

Wei Meijuan, YU Jin. Observation on effect of Chinese replenishing Kidney Drug on morphological change in rats with polycystic ovary. CJIM 1989;9(special collection): 10–12.

Chehab FF, Lim M, Lu R. Correction of the infertility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12:318.

Chehab FF, Mounzih K, Lu R, et al. Early onset of reproductive function in normal female mice treatment with leptin. Science 1997;275:88.

Yu WH, Kimura M, Walczewdka A, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94:1023–1028.

Aubert ML, Pierroz DD, Gruaz NM, et al. Metabolic control of sexual function and growth: role of neuropeptide Y and leptin. Mol Cell Endocrinol 1998; 140:107–113.

FULL TEXT LINK

More>

Views

410

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity

Effect of Tiangui Recipe on serum leptin and pituitary gonadotropin in androgen-sterilized rats

Protective Effects of Chaihu Shugan San (柴胡疏肝散) on Nonalcoholic Fatty Liver Disease in Rats with Insulin Resistance

Related Author

No data

Related Institution

Department of Food and Nutrition, Obesity/Diabetes Research Institutes, Hoseo University, Asan, South Korea

Daily Manufacturing Inc., Rockwell

School of Chinese Material Medica, Guangdong Pharmaceutical University

Center of Laboratorial Animals, Guangdong Pharmaceutical University

Guangdong Traditional Chinese Medicine Key Laboratory for Metabolic Diseases

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰