Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients

Yusheng Wu; Jianhui Yang; Liping Jiang; Zhankui Wang

doi:10.1007/BF02973135

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Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients

Updated：2021-08-27

- Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 6-9(2000)
- Affiliations：
  
  1. General Hospital of Jinan Military Region,Jinan
  2. The Affiliated Hospital of Shandong University of TCM,china
- Author bio：
- Funds：
- DOI：10.1007/BF02973135
  CLC：
- Published：2000，
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Wu, Y., Yang, J., Jiang, L. et al. Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients., CJIM 6, 6–9 (2000). https://doi.org/10.1007/BF02973135

Yusheng Wu, Jianhui Yang, Liping Jiang, et al. Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients. [J]. Chinese Journal of Integrative Medicine 6(1):6-9(2000)
Wu, Y., Yang, J., Jiang, L. et al. Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients., CJIM 6, 6–9 (2000). https://doi.org/10.1007/BF02973135 DOI：

Yusheng Wu, Jianhui Yang, Liping Jiang, et al. Effect of buyang huanwu decoction on plasma thromboxane b2, 6-keto-prostaglandin f1α, endothelin and calcitonin gene related peptide in primary nephrotic syndrome patients. [J]. Chinese Journal of Integrative Medicine 6(1):6-9(2000) DOI： 10.1007/BF02973135.

摘要

Objective: To explore the mechanism of Buyang Huanwu Decoction (BYHWD) in treating primary nephrotic syndrome (PNS).Methods: Based on the treatment of prednisone acetate and cytoxan

two groups of PNS patients were treated with aspirin and persantin (western medicine group

35 patients) and BYHWD plus WM (TCM-WM group

35 patients) respectively. The effect on anticoagulation was observed and compared. Plasma levels of thromboxane B2 (TXB2 )

6-keto-prostaglandin F1α (6-K-PGF1α)

endothelin (ET)

calcitonin gene related peptide (CGRP) were determined before and after treatment

at the reducing dose and shifting to maintenance dose of prednisone. The therapeutic effect of the two groups were also observed. Another group of 30 healthy subjects was established for control.Results: The differences of TXB2

6-K-PGF1α

ET and CGRP between patients and healthy subjects were very significant before treatment (P < 0. 001). The above-mentioned 4 parameters improved synchronously with the clinical improvement in the therapeutic course and they were better in the TCM-WM group than those in the WM group (P < 0.001 )

and the complete remission rate of the former group was also higher than that of the latter (62.9 % vs 37.1 %

χ2 = 4.63

P < 0.05).Conclusion: BHD could improve the therapeutic effect in treating PNS through the mechanism of improving TXB2

6-K-PGF1α

ET and CGRP levels.

Abstract

Objective: To explore the mechanism of Buyang Huanwu Decoction (BYHWD) in treating primary nephrotic syndrome (PNS).Methods: Based on the treatment of prednisone acetate and cytoxan

two groups of PNS patients were treated with aspirin and persantin (western medicine group

35 patients) and BYHWD plus WM (TCM-WM group

35 patients) respectively. The effect on anticoagulation was observed and compared. Plasma levels of thromboxane B2 (TXB2 )

6-keto-prostaglandin F1α (6-K-PGF1α)

endothelin (ET)

calcitonin gene related peptide (CGRP) were determined before and after treatment

6-K-PGF1α

and the complete remission rate of the former group was also higher than that of the latter (62.9 % vs 37.1 %

χ2 = 4.63

P < 0.05).Conclusion: BHD could improve the therapeutic effect in treating PNS through the mechanism of improving TXB2

6-K-PGF1α

ET and CGRP levels.

关键词

Buyang Huanwu Decoctionprimary nephrotic syndromethromboxane B26-keto-prostaglandin F1αendothelincalcitonin gene related peptide

Keywords

Buyang Huanwu Decoctionprimary nephrotic syndromethromboxane B26-keto-prostaglandin F1αendothelincalcitonin gene related peptide

references

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Wu YS, Yang JH, Luo NP, et al. The effect of Buyang Huanwu decoction in ET, CGRP of chronic nephritis. J Anhui College of TCM 1998;17(3):12–13.

Feng L, Huang J, Lin ZQ. The relationship between renal blood flow of diabetes mellitus patients and ET, CGRP. J Chin Nephrol 1998;14(1):37–38.

Wang HY, Zheng FL, Liu YC, et al. Minutes of symposium on typing, treatment and diagnostic standard of primary glomerulonephropathy. J Chin Int Med 1993; 32(2):131–134.

Yu XQ, Li HQ, Ye RG, et al. The change of ET in chronic nephropathy and its significance. J Chin Nephro 1995;11(1):91–92.

Ma XF, Zhang TJ. The current status on applying of CGRP in cardiovascular diseases and its prospect. Prog Cardiol 1993; 14(6):360–361.

Han YL, Chen SC. The molecular and cellular mechanism in regulating cardiovascular function by endothelin. Prog Cardiolo 1994; 15(6): 362–363.

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Deng CQ, Ge JW, Wang Q, et al. The comparison of effect on Astragalus and activating blood circulation recipe on TXA2, PGI2 of rabbit brain reperfusion injury and on cyclonucleotide. CJIM 1995; 15(3): 165–167.

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Related Institution

Jinan Municipal Hospital of TCM

Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine

Department of Neurobiology, Xiangya Medical College, Central South University

Department of Neurology, Xiangya Hospital, Central South University

Institute of the Integration of Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, Central South University

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