Objective: To investigate the effects on myocardial injury and sarcoplasmic reticulum (SR) Ca2+ - ATPase of viral myocarditis mice treated with Astragaloside (AS) and Astragalus Injection (AI).Methods: Viral myocarditis model was created by intraperitoneal inoculation with coxsackievirus B3m (CVB3m ) solution and were divided into model

AS

AI and normal control groups. The mortality

myocardial pathological changes

serum cardiac troponin I (cTnl) and the activity of myocardial Sarco/Endoplasmic Ca2+-ATPase (SER-CA) were observed.Results: The mortality of model was higher than that of the normal control (P = 0. 0042)

AS and AI (P<0.05). The serum level of cTnl of model was significantly higher than that of the normal control (P<0.001)

AS (P<0.025) and AI (P < 0.05). The myocardial necrosis and inflammatory changes of AS and AI groups were alleviated than that of model (P < 0.01). The activity of myocardial SERCA of model were significantly lower than that of normal control (P<0.001)

AS (P<0.01) and AI (P < 0.05).Conclusions: AS and AI have some protecting effects on myocardial injury of viral myocarditis mice. AS is the effective component ofAstragalus membranaceus in treating viral myocarditis. One of the mechanisms ofAstragalus membranaceus and AS for viral myocarditis mice depriving of the myocardial injury may be due to improve the activity of myocardial SERCA in the mice.