Jia, Y., Yu, L., Chen, Y. et al. Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits., CJIM 6, 21 (2000). https://doi.org/10.1007/BF02973140
Yuhua Jia, Linzhong Yu, Yuyao Chen, et al. Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits. [J]. Chinese Journal of Integrative Medicine 6(1):21(2000)
Jia, Y., Yu, L., Chen, Y. et al. Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits., CJIM 6, 21 (2000). https://doi.org/10.1007/BF02973140DOI:
Yuhua Jia, Linzhong Yu, Yuyao Chen, et al. Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits. [J]. Chinese Journal of Integrative Medicine 6(1):21(2000) DOI: 10.1007/BF02973140.
Effect of dingxin recipe on arrhythmia and injury induced by ischemia and reperfusion in rabbits
摘要
Objective: To investigate the protective effect of Dingxin Recipe (DXR) on arrhythmia and injury induced by ischemia and reperfusion.Methods: Rabbits were randomly divided into four groups and administered orally with DXR of high dose
low dose
propanolol and distilled water. Two-step coronary artery ligature was used to form ischemia and reperfusion model. Superoxide dismutase (SOD)
cyclic adenosine monophosphate (cAMP)
norepinephrine (NE)
dopamine (DA)
5-hydroxytryptamine (5-HT)
myocyte ultrastructural injury and occurrence of arrhythmia were investigated.Results: DXR could obviously antagonize arrhythmia induced by myocardial infarction or ischemia and reperfusion in rabbits. Compared with the control group
DXR of high and low doses could improve the changes in ST-T. In rabbits treated with DXR
the levels of SOD were elevated while cAMP
NE
DA
5-HT and the whole blood viscosity were lowered.Conclusions: DXR could obviously antagonize arrhythmia and injury induced by ischemia and reperfusion
DXR may clear oxygen free radical
regulate the second messenger
inhibit sympathetic nerve system
improve local circulation
protect mitochondria and prevent the activation of lysosome and safeguard the cardiac myocyte to be free from injury.
Abstract
Objective: To investigate the protective effect of Dingxin Recipe (DXR) on arrhythmia and injury induced by ischemia and reperfusion.Methods: Rabbits were randomly divided into four groups and administered orally with DXR of high dose
low dose
propanolol and distilled water. Two-step coronary artery ligature was used to form ischemia and reperfusion model. Superoxide dismutase (SOD)
cyclic adenosine monophosphate (cAMP)
norepinephrine (NE)
dopamine (DA)
5-hydroxytryptamine (5-HT)
myocyte ultrastructural injury and occurrence of arrhythmia were investigated.Results: DXR could obviously antagonize arrhythmia induced by myocardial infarction or ischemia and reperfusion in rabbits. Compared with the control group
DXR of high and low doses could improve the changes in ST-T. In rabbits treated with DXR
the levels of SOD were elevated while cAMP
NE
DA
5-HT and the whole blood viscosity were lowered.Conclusions: DXR could obviously antagonize arrhythmia and injury induced by ischemia and reperfusion
DXR may clear oxygen free radical
regulate the second messenger
inhibit sympathetic nerve system
improve local circulation
protect mitochondria and prevent the activation of lysosome and safeguard the cardiac myocyte to be free from injury.