Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome

Zhaoshun Jiang; Shenglan Zhang; Tianqin Kou; Wanjia Xing; Hui Yan; Geping Yin

doi:10.1007/BF02973141

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Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome

Updated：2021-08-27

- Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 22-24(2000)
- Affiliations：
  
  1. General Hospital of Jinan Military Region,Jinan
  2. Jining Hospital of Traditional Chinese Medicine,china
- Author bio：
- Funds：
- DOI：10.1007/BF02973141
  CLC：
- Published：2000，
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Jiang, Z., Zhang, S., Kou, T. et al. Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome., CJIM 6, 22–24 (2000). https://doi.org/10.1007/BF02973141

Zhaoshun Jiang, Shenglan Zhang, Tianqin Kou, et al. Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome. [J]. Chinese Journal of Integrative Medicine 6(1):22-24(2000)
Jiang, Z., Zhang, S., Kou, T. et al. Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome., CJIM 6, 22–24 (2000). https://doi.org/10.1007/BF02973141 DOI：

Zhaoshun Jiang, Shenglan Zhang, Tianqin Kou, et al. Exploration on significance of platelet cd62p, cdp63 determination in type 2 diabetes mellitus patients with blood stasis syndrome. [J]. Chinese Journal of Integrative Medicine 6(1):22-24(2000) DOI： 10.1007/BF02973141.

摘要

Objective: To study the relationship between blood stasis syndrome (BSS) and platelet activation and its influencing factors in type 2 diabetic mellitus (DM).Methods: Platelet CD62p

CD63 expressions were determined in 30 type 2 DM patients with BSS

27 type 2 DM patients without BSS and 20 normal controls by flow cytometry.Results: CD62p

CD63 levels were significantly higher in type 2 DM group with BSS than those in the type 2 DM group without BSS and in the normal controls. CD62p was positively correlated with CD63

while positive correlation existed between HbA1c

LDL-C and CD62p in DM patients with BSS.Conclusions: The increased level of platelet activation was the primary molecular basis of BSS in type 2 DM. It was important to perform the syndrome differentiation of BSS and treatment of activating blood flow to remove BSS in type 2 DM.

Abstract

Objective: To study the relationship between blood stasis syndrome (BSS) and platelet activation and its influencing factors in type 2 diabetic mellitus (DM).Methods: Platelet CD62p

CD63 expressions were determined in 30 type 2 DM patients with BSS

27 type 2 DM patients without BSS and 20 normal controls by flow cytometry.Results: CD62p

CD63 levels were significantly higher in type 2 DM group with BSS than those in the type 2 DM group without BSS and in the normal controls. CD62p was positively correlated with CD63

while positive correlation existed between HbA1c

关键词

type 2 diabetes mellitusplatelet activationBlood Stasis SyndromeFlow Cytometry

Keywords

type 2 diabetes mellitusplatelet activationBlood Stasis SyndromeFlow Cytometry

references

WHO Study Group on Diabetes Mellitus. Technical Report Series. WHO Geneva 1985:727-729.

Ministry of Health, P. R. China. Guidelines of the clinical research of new drugs. 1993:82-85.

Sedlmayr P, Grobhaupt B, Muntean W. Flow cytometric detection of intracellular platelet antigens. Cytometry 1996; 23:284–289.

McEver RP, Beckested JH, Moore KL, et al. GMP-140, a platelet α-granule membrane protein is also synthesized by vascular endothelial cells and localized in Weibel-palade bodies. J Clin Invest 1989; 84:92–99.

Wang DB, Chen RX, Li JY, et al. Microvessel lesion and platelet function of diabetes mellitus patients. J Jiangsu Med 1994;20:121–123.

Schafer AI. Antiplatelet therapy. Am J Med 1996; 101:201–204.

Pan YZ, Wu BM, Hong XS, et al. The significance of platelet activation in non-stabilized angina pectoris. Chin J Cardiovasc 1994;22(4): 247–249.

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Academy of Chinese Medical Sciences

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