Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor

Changquan Ling; Min LI; Jinxing Tan; Junhua Lu

doi:10.1007/BF02973144

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Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor

Updated：2021-08-27

- Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 32-34(2000)
- Affiliations：
  
  1. Changhai Hospital. The Second Military Medical University,Shanghai
  2. The Public Sanitary Department of the Second Military Medical Univeristy,china
- Author bio：
- Funds：
  
  This study was supported by National Natural Science Foundation (No. 30670882)
- DOI：10.1007/BF02973144
  CLC：
- Published：2000，
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Ling, C., LI, M., Tan, J. et al. Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor., CJIM 6, 32–34 (2000). https://doi.org/10.1007/BF02973144

Changquan Ling, Min LI, Jinxing Tan, et al. Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor. [J]. Chinese Journal of Integrative Medicine 6(1):32-34(2000)
Ling, C., LI, M., Tan, J. et al. Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor., CJIM 6, 32–34 (2000). https://doi.org/10.1007/BF02973144 DOI：

Changquan Ling, Min LI, Jinxing Tan, et al. Experimental study on protective effect of chinese herbal medicine on glucocorticoid receptor. [J]. Chinese Journal of Integrative Medicine 6(1):32-34(2000) DOI： 10.1007/BF02973144.

摘要

Objective: To probe the relationship of glucocorticoid receptor and some Chinese medicinal herbs.Methods: The model of Qi-Yang exhaustion and Qi-Yin exhaustion were made with hemorrhagic rats and heat-stressed rats respectively. The effect of Shenfu decoction (SFD) and Shengmai powder (SMP) on plasma glucocorticoid (GC) and its receptor (GcR) in hepatic cytosol of the models were measured respectively.Results: The activity of GcR decreased in both models

while their blood level of GC increased markedly. SFD and SMP showed no regulating effect on blood GC

but displayed obvious up-regulation on GcR level in both models.Conclusion: SFD and SMP could up-regulate the activity of GcR in Qi-Yang and Qi-Ying exhaustion models.

Abstract

while their blood level of GC increased markedly. SFD and SMP showed no regulating effect on blood GC

but displayed obvious up-regulation on GcR level in both models.Conclusion: SFD and SMP could up-regulate the activity of GcR in Qi-Yang and Qi-Ying exhaustion models.

关键词

Shenfu decoctionShengmai powderglucocorticoid receptor

Keywords

Shenfu decoctionShengmai powderglucocorticoid receptor

references

Zhang JQ, Tan JX, Liu ZQ. Alteration of GcR on hepatic cytosol in models of “Yang-deficiency” animals and action of support Yang medicine. CJIM 1984; 4 (2): 107–108.

Zhang JQ, Liu ZM. The diversification of single nucleus and polymorphic nucleus WBC GcR in ”Yang-deficiency ”patients. CJIM 1990; 10(4):215- 216.

Xu KC, Zhang SC. Experimental study on GcR of hepatic cytosol in hyperthyroidism rats. Guangzhou J Tradit Chin Institute 1990;7(3): 145–149.

Tan JX, Xu RB. Improvement on determination methods of GcR. Progress in Biochemistry and Biophysics 1987;4:56–58.

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Cardiovascular Department of Xinhua Hospital Affiliated to Shanghai Second Medical University

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