Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats

Ningjun Li; Jingzi Li; Gang Xin; Yuan Xu; Jianmei Hong; Haiyan Wang

doi:10.1007/BF02973145

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Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats

Updated：2021-08-27

- Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 35-37(2000)
- Affiliations：
  
  The First Hospital of Beijing Medical University,Beijing
- Author bio：
- Funds：
  
  This study was supported by National Natural Science Foundation (No. 39670909)
- DOI：10.1007/BF02973145
  CLC：
- Published：2000，
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Li, N., Li, J., Xin, G. et al. Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats., CJIM 6, 35–37 (2000). https://doi.org/10.1007/BF02973145

Ningjun Li, Jingzi Li, Gang Xin, et al. Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats. [J]. Chinese Journal of Integrative Medicine 6(1):35-37(2000)
Li, N., Li, J., Xin, G. et al. Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats., CJIM 6, 35–37 (2000). https://doi.org/10.1007/BF02973145 DOI：

Ningjun Li, Jingzi Li, Gang Xin, et al. Effect of astragalus- angelica mixture on lipoprotein lipase and lecithin- cholesterol acyltransferase of nephrotic rats. [J]. Chinese Journal of Integrative Medicine 6(1):35-37(2000) DOI： 10.1007/BF02973145.

摘要

Objective: To investigate the mechanism of Astragalus-Angelica Mixture (AAM) ’s effects on lipid metabolism disturbance in nephrotic rats.Methods: To examine the effects of AAM on serum albumin

lipid levels

and activities of lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT)

which are key enzymes for metabolism of lipid in immune-induced nephrotic hyperlipidemia rats and exogenous hyperlipidemia rats.Results: In nephrotic rats

serum albumin was reduced

lipid increased significantly

LPL activity decreased markedly and the LCAT activity was relatively insufficient. Activities of LPL and LCAT increased obviously in AAM treated nephrotic rats. There were no change of activities of LPL and LCAT in exogenous hyperlipidemia rats and AAM showed no effect on the activities of these two enzymes.Conclusion: The effect of AAM on regulating lipid metabolism might be due to enhance the clearance of both triglyceride-rich and cholesterol-rich apoB containing lipoprotein by improving the activities of LPL and LCAT.

Abstract

Objective: To investigate the mechanism of Astragalus-Angelica Mixture (AAM) ’s effects on lipid metabolism disturbance in nephrotic rats.Methods: To examine the effects of AAM on serum albumin

lipid levels

and activities of lipoprotein lipase (LPL) and lecithin-cholesterol acyltransferase (LCAT)

which are key enzymes for metabolism of lipid in immune-induced nephrotic hyperlipidemia rats and exogenous hyperlipidemia rats.Results: In nephrotic rats

serum albumin was reduced

lipid increased significantly

关键词

Astragalus-Angelica MixtureNephrotic SyndromeLipoprotein Lipaselecithin-cholesterol acyltransferasehyperlipidemia

Keywords

Astragalus-Angelica MixtureNephrotic SyndromeLipoprotein Lipaselecithin-cholesterol acyltransferasehyperlipidemia

references

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Zhang XY, Cui RL, Li L, et al. Modified LCAT determination and its clinical significance in nephropathy. Nephropathy, Dialysis and Kidney Transplantation 1995; 4: 18.

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Wang HY, Li JZ, Yu H, et al. Effect of Tripterygium and Astragalus-Angelica on permeability of glomerular filtration membrane of microlesion in nephropathic rats. CMJ 1988; 68(9):513–515.

Li LY, Chen MH, Tong TJ, et al. The molecular basis of Chinese herbs (Astragali and Angelica) on increasing serum albumin synthesis in nephrotic rats. Nephrology 1998;4:1–6.

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Guangdong Provincial Institute of Cardiovascular Diseases

Department of Cardiology, Affiliated Hospital, Tongji Medical College, Huazhong University of Science and Technology

Institute of Traditional Chinese Medicine and Natural Products, Jinan University

Guangdong Provincial Institute of Traditional Chinese Medicine

Department of Hepatology, Zhejiang Hospital of Traditional Chinese Medicine

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