Experimental study on multi- lnfarct dementia treated with principle of yijing tishen

Hao Xu; Nianfang Shao; Meizeng Zhang; Xiangrong Ye; Weicheng Hu; Yanzhi Du; Xiuyun Liu

doi:10.1007/BF02973146

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Experimental study on multi- lnfarct dementia treated with principle of yijing tishen

Updated：2021-08-27

- Experimental study on multi- lnfarct dementia treated with principle of yijing tishen
- Chinese Journal of Integrative Medicine Vol. 6, Issue 1, Pages: 38-42(2000)
- Affiliations：
  
  1. Shandong University of Traditional Chinese Medicine,Jinan
  2. Shandong Medical Univeristy,china
- Author bio：
- Funds：
  
  Granted by Shandong Educational Commission (No. J95K37)
- DOI：10.1007/BF02973146
  CLC：
- Published：2000，
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Xu, H., Shao, N., Zhang, M. et al. Experimental study on multi- lnfarct dementia treated with principle of yijing tishen., CJIM 6, 38–42 (2000). https://doi.org/10.1007/BF02973146

Hao Xu, Nianfang Shao, Meizeng Zhang, et al. Experimental study on multi- lnfarct dementia treated with principle of yijing tishen. [J]. Chinese Journal of Integrative Medicine 6(1):38-42(2000)
Xu, H., Shao, N., Zhang, M. et al. Experimental study on multi- lnfarct dementia treated with principle of yijing tishen., CJIM 6, 38–42 (2000). https://doi.org/10.1007/BF02973146 DOI：

Hao Xu, Nianfang Shao, Meizeng Zhang, et al. Experimental study on multi- lnfarct dementia treated with principle of yijing tishen. [J]. Chinese Journal of Integrative Medicine 6(1):38-42(2000) DOI： 10.1007/BF02973146.

摘要

Objective: To explore the mechanism of multi-infarct dementia (MID) treated with the principle of Yijing Tishen (YJTS

reinforcing Kidney-essence and refreshing mental activities).Methods: MID rat models were established successfully with injecting sterile and naturally dried blood clots of the homologous rat into common carotid artery and screened by the first jumping-off latency of diving-platform reflex

based on which

the effect of YJTS in learning and memorizing

monoamine neurotransmitters content in brain tissue

malondialdehyde (MDA) content and Superoxide dismutase (SOD) activity in serum and brain tissue

and brain morphosis of multi-infarct rats were observed.Results: Obvious malfunction of learning and memorizing was found in MID rat models

and there were also significant decreasing of monoamine neurotransmitters content in partial brain zones

decreasing of SOD activity in brain and increasing of MDA content in serum and brain. YJTS could obviously improve learning and memorizing

raise SOD activity and monoamine neurotransmitters content in brain tissue

lower MDA content in serum and brain of MID rat models

protect brain morphosis of multi-infarct rats.Conclusion: YJTS might treat MID by restraining lipid peroxidation

improving monoamine neurotransmitters content in partial brain zones and decreasing ischemic damage of brain tissue.

Abstract

Objective: To explore the mechanism of multi-infarct dementia (MID) treated with the principle of Yijing Tishen (YJTS

based on which

the effect of YJTS in learning and memorizing

monoamine neurotransmitters content in brain tissue

malondialdehyde (MDA) content and Superoxide dismutase (SOD) activity in serum and brain tissue

and brain morphosis of multi-infarct rats were observed.Results: Obvious malfunction of learning and memorizing was found in MID rat models

and there were also significant decreasing of monoamine neurotransmitters content in partial brain zones

decreasing of SOD activity in brain and increasing of MDA content in serum and brain. YJTS could obviously improve learning and memorizing

raise SOD activity and monoamine neurotransmitters content in brain tissue

lower MDA content in serum and brain of MID rat models

protect brain morphosis of multi-infarct rats.Conclusion: YJTS might treat MID by restraining lipid peroxidation

improving monoamine neurotransmitters content in partial brain zones and decreasing ischemic damage of brain tissue.

关键词

principle of Yijing TishenVascular Dementiamalondialdehydesuperoxide dismutasemonoamine neurotransmitters

Keywords

principle of Yijing TishenVascular Dementiamalondialdehydesuperoxide dismutasemonoamine neurotransmitters

references

Xu H, Shao NF, Cui DZ, et al. Clinical study on effect of Yizhi capsule in preventing vascular dementia. J TCM 1997;38(8):480–482.

Xu H. Clinical study of Yijing Tishen principle in treating multi-infarct dementia. J Shandong Univer TCM 1998; 22 (2):111–114.

Li YK, chief-editor. Methodology of TCM pharmacological experiments. Shanghai: Shanghai Press of Science and Technology, 1991:173,186.

Chen JP, Tian SY, Yu WW, et al. Study on animal model of multi-infarct dementia. J Chin Neuro and Psychiatric 1994;(6): 311.

Wu J, Liu DS, Zhang Y, et al. Effect of Ibotenic acid injection at innominated zone to rats’ learning and memory. J Stroke and Neurological Disease 1991; (3): 133.

Schmidley JW. Free radicals in central nervous system ischemia. Stroke 1990; 21:1086.

Li H, Zheng YS. Effect of Naomaibao at post-cerebral ischemia reperfusion monoamine neurotransmitters in rats. Chin Drugs Pharmacology and Clinics 1995; (5):34.

Xu H, Shao HQ, Hu CY, et al. Effect of Yizhi capsule on serum Ca, Mg, Cu, Fe, Zn and Se of multi-infarct dementia rats. Chin New Drugs and Clin Pharmacology 1998;9. (3):166.

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