Objective: To investigate the clinical effect of Xinqingning (XQN)

a preparation of rhubarb

combined with low dose continuous gastrointestinal dialysis in treating uremia.Methods: Patients of uremia were divided into three groups at random

18 patients in group A were treated with 1000 ml gastrointestinal dialysate (non-absorbed mannitol solution) orally 2–3 times a day

20 patients in group B treated with the same therapy as that in group A

also combined with XQN 5–10 tablets 3 times per day and 19 patients in group C treated with orally taken coated aldehyde oxystarch 5–10 g

3 times a day. The therapeutic course for the three groups was 11 months. The changes in clinical manifestation

renal function

nutritional condition

and electrolytes before and after treatment were observed.Results: After treatment

significant improvement was revealed in aspects of uremic symptoms

quality of life

nutritional condition

serum creatinine

urea nitrogen

serum phosphate

uric acid

CO2 combining power

creatine clearance

body weight and arm muscular circumference in group A and B

as compared with those in group C. In comparison of group A with B

group B showed a lower serum triglyceride and a slower progression of chronic renal failure (CRF). All the criteria were not improved in group C and with serum creatinine being raised significantly.Conclusion: XQN combined with low dose continuous gastrointestinal dialysis therapy was definitely effective in treating uremia. It provides a new therapeutic means of non-replacement therapy for CRF with uremia.