Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica

Yin Zong-zhu M. D.; Jin Hai-ling; Yin Xue-zhe; Quan Ji-shu; Jin Ming; Piao Chun-mei; Zhang Hong-ying

doi:10.1007/BF03178491

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Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica

Updated：2021-08-27

- Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica
- Chinese Journal of Integrative Medicine Vol. 7, Issue 3, Pages: 209-213(2001)
- Affiliations：
  
  Department of Biochemistry, College of Medicine, Yanbian University, Yanji
- Author bio：
- Funds：
  
  This work was supported by a grant from the National Natural Science Foundation of China (No. 39660021)
- DOI：10.1007/BF03178491
  CLC：
- Published：2001，
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Yin, Zz., Jin, Hl., Yin, Xz. et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica, ., CJIM 7, 209 (2001). https://doi.org/10.1007/BF03178491

Yin Zong-zhu M. D., Jin Hai-ling, Yin Xue-zhe, et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica. [J]. Chinese Journal of Integrative Medicine 7(3):209-213(2001)
Yin, Zz., Jin, Hl., Yin, Xz. et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica, ., CJIM 7, 209 (2001). https://doi.org/10.1007/BF03178491 DOI：

Yin Zong-zhu M. D., Jin Hai-ling, Yin Xue-zhe, et al. Anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica. [J]. Chinese Journal of Integrative Medicine 7(3):209-213(2001) DOI： 10.1007/BF03178491.

摘要

Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker

GST-P

p53 and p21ras proteins in promotion stage of rat chemical hepatocarcinogenesis were examined by immunohistochemical technique ABC method. Anti-tumor effect of BR was investigated by inhibitory test on Sarcoma180. Anti-inflammatory activity of BR was tested by xylene-induced mouse ear swelling method.Results: BR-H2O extract (the H2O extract fractionated from BR-Methanol extract with CH2Cl2 and H2O) 500 mg/kg has inhibitory effect on the formation of diethylnitrosamine (DEN)-induced glutathione S-transferase placental form (GST-P) positive foci in rat liver with the expression of mutant p53 and p21ras proteins lower than those of non-treated hepatic preneoplastic lesions. BR extract showed inhibitory effect on Sarcoma180 and anti-inflammatory effect in mice by xylene-induced mouse ear swelling tests.conclusion: BR-H2O extract exerted inhibitory effect on DEN-induced preneoplastic hepatic foci in promotion stage of rat chemical hepatocarcinogenesis and might suppress the growth of solid Sarcoma180 in mice. Both CH2Cl2 and H2O extract from BR exerted anti-inflammatory effect in mice.

Abstract

Objective: To investigate the anti-tumor effect and anti-inflammatory activity ofBoschniakia rossica (BR).Methods: The expression of tumor marker

GST-P

关键词

Boschniakia rossicaplacental form glutathione S-transferasep53chemical hepatocarcinogenesisSarcoma180anti-inflammation

Keywords

Boschniakia rossicaplacental form glutathione S-transferasep53chemical hepatocarcinogenesisSarcoma180anti-inflammation

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