Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution

Qian Yue-sheng; Zhou Xiao-ou; Zhang Yi; Gao Ping-jin; Zhang Wei-zhong; Zhu Ding-liang

doi:10.1007/s11655-007-0175-9

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Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution

Updated：2021-08-27

- Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution
- Chinese Journal of Integrative Medicine Vol. 13, Issue 3, Pages: 175-179(2007)
- Affiliations：
  
  Ruijin Hospital, Medical School of Shanghai Jiaotong University, Shanghai Institute of Hypertension,Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-007-0175-9
  CLC：
- Published：2007，
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Qian, Ys., Zhou, Xo., Zhang, Y. et al. Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution., Chin. J. Integr. Med. 13, 175–179 (2007). https://doi.org/10.1007/s11655-007-0175-9

Qian Yue-sheng, Zhou Xiao-ou, Zhang Yi, et al. Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution. [J]. Chinese Journal of Integrative Medicine 13(3):175-179(2007)
Qian, Ys., Zhou, Xo., Zhang, Y. et al. Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution., Chin. J. Integr. Med. 13, 175–179 (2007). https://doi.org/10.1007/s11655-007-0175-9 DOI：

Qian Yue-sheng, Zhou Xiao-ou, Zhang Yi, et al. Study on insulin resistance and genetic polymorphisms in essential hypertension patients of two different kinds of TCM constitution. [J]. Chinese Journal of Integrative Medicine 13(3):175-179(2007) DOI： 10.1007/s11655-007-0175-9.

摘要

To investigate the relationship of insulin resistance and the polymorphisms of insulin receptor-related genes in essential hypertension patients of two different kinds of TCM constitution. Oral glucose tolerance test (OGTT) and insulin release test (InRT) were conducted in 217 essential hypertensive patients of either sluggish meticulous (SM) constitution (139 cases) or prosperous impetuous (PI) constitution (78 cases)

and the polymorphism of three genes

including insulin-like growth factor-1 receptor (IGF-1R)

insulin receptor substrate-1 (IRS-1) and 2 (IRS-2) genes were detected. (1) OGTT

InRT and insulin resistance index (Homa-IR) were higher and insulin sensitive index (ISI) was lower in the patients of SM constitution than those in patients of PI constitution. (2) Significant difference of ISI and Homa-IR was shown in patients of both constitutions with genotype G of the 3 genes. Decrease of insulin sensitivity and increase of insulin resistance are more obvious in hypertensive patients with genotype G of the 3 genes of SM constitution than in those of PI constitution. Therefore

the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients.

Abstract

and the polymorphism of three genes

including insulin-like growth factor-1 receptor (IGF-1R)

insulin receptor substrate-1 (IRS-1) and 2 (IRS-2) genes were detected. (1) OGTT

the difference in constitution might be one of the genetic characteristics for insulin resistance in hypertensive patients.

关键词

Essential Hypertensioninsulin resistanceconstitution classificationpolymorphism of geneprosperous impetuous constitutionsluggish meticulous constitution

Keywords

Essential Hypertensioninsulin resistanceconstitution classificationpolymorphism of geneprosperous impetuous constitutionsluggish meticulous constitution

references

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