Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease

Shen Li; Xiang-rong Rao; Su-xia Wang; Gai-hua Zhang; Xiao-mei Li; Xi-wen Dai; Ke-ji Chen

doi:10.1007/s11655-009-0170-4

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Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease

Updated：2021-08-27

- Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease
- Chinese Journal of Integrative Medicine Vol. 15, Issue 3, Pages: 170-176(2009)
- Affiliations：
  
  1. Department of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Nephrology, the First Hospital of Peking University,Beijing,China
  3. Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by Scientific Research Fund of State Administration of Traditional Chinese Medicine of the P. R. China (No. 04-05JQ07)
- DOI：10.1007/s11655-009-0170-4
  CLC：
- Published：2009，
  
  Published Online：2 July 2009，
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Li, S., Rao, Xr., Wang, Sx. et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease., Chin. J. Integr. Med. 15, 170–176 (2009). https://doi.org/10.1007/s11655-009-0170-4

Shen Li, Xiang-rong Rao, Su-xia Wang, et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease. [J]. Chinese Journal of Integrative Medicine 15(3):170-176(2009)
Li, S., Rao, Xr., Wang, Sx. et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease., Chin. J. Integr. Med. 15, 170–176 (2009). https://doi.org/10.1007/s11655-009-0170-4 DOI：

Shen Li, Xiang-rong Rao, Su-xia Wang, et al. Study on the relationship between blood stasis syndrome and clinical pathology in 227 patients with primary glomerular disease. [J]. Chinese Journal of Integrative Medicine 15(3):170-176(2009) DOI： 10.1007/s11655-009-0170-4.

摘要

To investigate the relationship between the severity of Chinese medicine (CM) bloodstasis syndrome (BSS) with clinical features and renal lesion indexes of the primary glomerular disease. An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases

and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age

course of glomerular diseases

24-h urine protein ration (Upro)

hypertension and blood pressure (BP) progress

serum creatinine levels (Scr)

estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR)

blood urea nitrogen (BUN)

uric acid (UA)

triglyceride (TG)

cholesterol (CHO)

haematoglobin (HGB)

albumin (ALB)

and the correlation among renal pathological types

pathology lesion indexes

and BSS scores. (1) Among the 227 patients

207 (91.19%) were diagnosed as BSS

in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age

gender

grades of the hypertension

and the BSS score. Multiple stepwise regression analysis showed that Upro

CHO

and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology

especially the tubular atrophy and interstitial fibrosis. The severity of proliferation and glomerular sclerosis was accompanied with higher BSS scores with a significant difference (P<0.05). BSS is one of the most common CM syndromes among patients with the primary glomerular diseases; the BSS score has a positive correlation with Upro

CHO

eGFR

as well as the index of chronic renal pathology. Based on these observations

the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.

Abstract

and their severity of BSS were scored three days before renal biopsies were performed. The following clinical indexes were analyzed: age

course of glomerular diseases

24-h urine protein ration (Upro)

hypertension and blood pressure (BP) progress

serum creatinine levels (Scr)

estimation of glomerular filtration rate based on the predigesting equation of MDRD (eGFR)

blood urea nitrogen (BUN)

uric acid (UA)

triglyceride (TG)

cholesterol (CHO)

haematoglobin (HGB)

albumin (ALB)

and the correlation among renal pathological types

pathology lesion indexes

and BSS scores. (1) Among the 227 patients

207 (91.19%) were diagnosed as BSS

in which 95 cases were considered as moderate and the rest 112 cases as severe. (2) There was a negative correlation between age

gender

grades of the hypertension

and the BSS score. Multiple stepwise regression analysis showed that Upro

CHO

and eGFR were positively related to the BSS score (P<0.05). (3) The BSS score has a positive correlation with indexes of chronic renal pathology

CHO

eGFR

as well as the index of chronic renal pathology. Based on these observations

the BSS may be used as an indicator of the development of renal diseases. Being positively diagnosed as BSS could indicate the beginning of the chronic phase of the primary glomerular diseases.

关键词

primary glomerular diseasesblood-stasis syndromeclinical indexpathology of the renal biopsy

Keywords

primary glomerular diseasesblood-stasis syndromeclinical indexpathology of the renal biopsy

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Related Institution

Graduate School, Beijing University of Chinese Medicine

Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Department of Cardiovascular Disease, Xiyuan Hospital, China Academy of Traditional Chinese Medicine

Department of Dermatology, Guangdong Provincial Hospital of Traditional Chinese Medicine

Faculty of Traditional Chinese Medicine, Medical School of Jinan University

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