Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome

Feng Pan; Tao Zhang; Yong-hua Zhang; Jian-jun Xu; Fang-ming Chen

doi:10.1007/s11655-009-0216-7

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Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome

Updated：2021-08-27

- Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome
- Chinese Journal of Integrative Medicine Vol. 15, Issue 3, Pages: 216-219(2009)
- Affiliations：
  
  1. Department of Digestive Diseases, Zhejiang Provincial Hospital of Integrated Chinese and Western Medicine,Hangzhou,China
  2. Institute of Pi-Wei, Guangzhou University of Traditional Chinese Medicine,Guangzhou,China
  3. Zhejiang University of Traditional Chinese Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the Fund of Hangzhou Municipal Science and Technology Administration (No. 20070433Q24)
- DOI：10.1007/s11655-009-0216-7
  CLC：
- Published：2009，
  
  Published Online：2 July 2009，
Scan for full text
Pan, F., Zhang, T., Zhang, Yh. et al. Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome., Chin. J. Integr. Med. 15, 216–219 (2009). https://doi.org/10.1007/s11655-009-0216-7

Feng Pan, Tao Zhang, Yong-hua Zhang, et al. Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome. [J]. Chinese Journal of Integrative Medicine 15(3):216-219(2009)
Pan, F., Zhang, T., Zhang, Yh. et al. Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome., Chin. J. Integr. Med. 15, 216–219 (2009). https://doi.org/10.1007/s11655-009-0216-7 DOI：

Feng Pan, Tao Zhang, Yong-hua Zhang, et al. Effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome. [J]. Chinese Journal of Integrative Medicine 15(3):216-219(2009) DOI： 10.1007/s11655-009-0216-7.

摘要

To study the clinical effect of Tongxie Yaofang (痛泻要方) Granule in treating diarrhea-predominate irritable bowel syndrome (D-IBS) and its possible mechanism. A total of 120 patients were assigned to two groups using stratified block randomization

80 in the intervention group and 40 in the control group. To the intervention group the TXYF granule was given at one package each time

twice a day; the control group was treated with Miyarisan three times a day

two tablets each time. The course of treatment was 4 weeks for both groups. The total efficacy in them was compared

and data of scoring on stool (Bristol method)

abdominal pain

abdominal distension

and mental condition were collected before treatment and 2 and 4 weeks after treatment. The activation of mast cells (MCs) of six patients chosen from each group was detected as well before and after treatment. No significant difference between the two groups in terms of the total efficacy or the scores of symptoms before and after treatment was found (P>0.05). The number of activated MCs was decreased in the intervention group after treatment

showing significant difference as compared with that before treatment as well as with that in the control group after treatment (P<0.01). TXYF is an effective preparation for the treatment of D-IBS. It can quickly lessen abdominal pain and distention

improve the property of stool

and improve mental tension and depression in patients. Its mechanism of action might be through the adjustment of MCs activation to decrease visceral hypersensitivity.

Abstract

80 in the intervention group and 40 in the control group. To the intervention group the TXYF granule was given at one package each time

twice a day; the control group was treated with Miyarisan three times a day

two tablets each time. The course of treatment was 4 weeks for both groups. The total efficacy in them was compared

and data of scoring on stool (Bristol method)

abdominal pain

abdominal distension

improve the property of stool

and improve mental tension and depression in patients. Its mechanism of action might be through the adjustment of MCs activation to decrease visceral hypersensitivity.

关键词

Tongxie Yaofang Granulediarrhea-predominate irritable bowel syndromeClinical Observation

Keywords

Tongxie Yaofang Granulediarrhea-predominate irritable bowel syndromeClinical Observation

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Department of Integrative Medicine, Shandong Provincial Hospital Affiliated to Shandong University

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