Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula

Shao-tang Li; Bo Cao; Wen-Ling Deng; Zhi Li

doi:10.1007/s11655-009-0279-5

Your Location：

Home >

Browse articles >

Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula

Updated：2021-08-27

- Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula
- Chinese Journal of Integrative Medicine Vol. 15, Issue 4, Pages: 279-283(2009)
- Affiliations：
  
  1. Fujian Medical University,Fuzhou,China
  2. Department of Anorectal Diseases, the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang,China
- Author bio：
- Funds：
  
  Supported by the Funds of Guiyang College of Traditional Chinese Medicine (No. 200607)
- DOI：10.1007/s11655-009-0279-5
  CLC：
- Published：2009，
  
  Published Online：18 August 2009，
Scan for full text
Li, St., Cao, B., Deng, WL. et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula., Chin. J. Integr. Med. 15, 279–283 (2009). https://doi.org/10.1007/s11655-009-0279-5

Shao-tang Li, Bo Cao, Wen-Ling Deng, et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula. [J]. Chinese Journal of Integrative Medicine 15(4):279-283(2009)
Li, St., Cao, B., Deng, WL. et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula., Chin. J. Integr. Med. 15, 279–283 (2009). https://doi.org/10.1007/s11655-009-0279-5 DOI：

Shao-tang Li, Bo Cao, Wen-Ling Deng, et al. Clinical study of external application of Qiyu oil (芪榆油) gauze for promoting post-operational healing in patients with anal fistula. [J]. Chinese Journal of Integrative Medicine 15(4):279-283(2009) DOI： 10.1007/s11655-009-0279-5.

摘要

To observe the effects of the external application of Qiyu oil (芪榆油) gauze (QYOG) for promoting post-operational healing in patients with anal fistula and to explore its mechanism of action so as to provide a beneficial scientific basis for its wide use. Sixty patients with anal fistula scheduled to receive simple low anal fistulectomy were equally assigned

according to the sequence of hospitalization

to the tested group and the control group

and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II

2–5 cm; and Grade III

over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide

the wound substratum was packed with QYOG in the test group and with vaseline gauze in the control group. The packing gauze was changed every day till the wound was healed. The healing time of the patients was observed

and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF)

basic fibroblast growth factor (bFGF)

and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. The wound healing time was 17.80±5.46 days in the test group

which was significantly shorter than that in the control group (21.90±6.32 days

P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01)

though the difference in EGF between the two groups was insignificant (P>0.05). QYOG could shorten the wound healing time after anal fistulectomy

which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF

and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.

Abstract

according to the sequence of hospitalization

to the tested group and the control group

and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II

2–5 cm; and Grade III

over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide

and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF)

basic fibroblast growth factor (bFGF)

and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation. The wound healing time was 17.80±5.46 days in the test group

which was significantly shorter than that in the control group (21.90±6.32 days

P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01)

though the difference in EGF between the two groups was insignificant (P>0.05). QYOG could shorten the wound healing time after anal fistulectomy

which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF

and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.

关键词

Qiyu oil gauzeanal fistulawound healingvascular endothelial growth factorbasic fibroblast growth factorepidermal growth factornumber of blood capillary

Keywords

Qiyu oil gauzeanal fistulawound healingvascular endothelial growth factorbasic fibroblast growth factorepidermal growth factornumber of blood capillary

references

State Administration of Traditional Chinese Medicine, P. R. China. Standard for diagnosis and efficacy evaluation of traditional Chinese medicine diseases and syndromes. Nanjing: Nanjing University Press;1994:186.

Zhang Y, Hu G, Hong SL, Lao SC, Lee MY, Wang YT. The proangiogenic effect of Radix Astragli extract in human endothelial cells (HUVEC). Pharmocol Clin Chin Mater Med (Chin) 2007;23:34–37

Zhou JB, Zhao Y, Zhu HQ, Pan LQ. Effect of Danshen Yaomo on PDGF expression of gastric wound tissues. Shandong Tradit Chin Med (Chin) 2005;24:105–106.

Fu XB, Wang DW, eds. Contemporary trauma and repair. 1st ed. Beijing: People’s Military Medical Press; 1999:245–248.

Tian JG, Xia ZF. Research progress on wound dressing of burn. Med J Chin People Liber Army (Chin) 2003;28:470.

Zhang J, Niu XT, Li D. Comparative research of the donor site wound healing in occlusive and dry environments. Chin J Repar Reconstr Surg (Chin) 2004;18:152–155.

Hu Y. An analysis of 112 cases treated with closed moist therapy. Acta Univ Med Nanjing (Chin) 2003;23:183–184.

Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Sterm Cells 2002;20:530–541.

Toma JG, Akhavan M, Fernandes KJ, Barnabé-Heider F, Sadikot A, Kaplan DR, et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001;(9):778–784.

Seghezzi G, Pate S, Ren CJ, Gualandris A, Pintucci G, Robbins ES, et al. Fibroblast growth factor-2 (FGF-2) induced vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis. J Cell Biol 1998;141:1659–1673.

Numata Y, Terui T, Okuyama R, Hirasawa N, Sugiura Y, Miyoshi I, et al. The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor. J Invest Dermatol 2006;126:1403–1409.

Yanaka A, Suzuki H, Shibahara A, Matsui H, Nakahara A, Tananka N. EGF promotes gastric mucosal restitution by activating Na(+)/H(+) exchange of epithelial cells. Am J Physiol Gestrointest Liver Physiol 2002;282:G866–G876.

Liu Y, Zhong XL, Tian WY. Mechanism of action to accelerate second deep degree scald wound healing by endogenous EGF. Med J Natl Defend Forces Northwest China (Chin) 2001;22:214–217.

FULL TEXT LINK

More>

Views

355

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Celastrus Orbiculatus Extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in Vitro and in Vivo

Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

In Vitro antimetastatic effect of Changweiqing (肠胃清) through antiinvasion of hypoxic colorectal carcinoma LoVo cells

Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion

Effects of Huanshuai Recipe Oral Liquid (缓衰口服液) on restructuring glomerular microvasculature and expression of vascular endothelial growth factor in subtotal nephrectomized rats

Related Author

No data

Related Institution

Department of Physiology, School of Medicine, Showa University

Department of Image, 97th Hospital of People’s Liberation Army

Institute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University

Nanjing University of Traditional Chinese Medicine

Children’s Hospital of Soochow University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰