Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion

Fang Liu; Song-ping Luo

doi:10.1007/s11655-009-0353-z

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Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion

Updated：2021-08-27

- Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion
- Chinese Journal of Integrative Medicine Vol. 15, Issue 5, Pages: 353-358(2009)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Shenzhen Maternity and Child Healthcare Hospital Affiliated to Southern Medical University,Guangdong Province,China
  2. Department of Gynecology, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by Guangdong Province Key Scientific and Technological Project (No. C30103)
- DOI：10.1007/s11655-009-0353-z
  CLC：
- Published：2009，
  
  Published Online：3 October 2009，
Scan for full text
Liu, F., Luo, Sp. Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion., Chin. J. Integr. Med. 15, 353–358 (2009). https://doi.org/10.1007/s11655-009-0353-z

Fang Liu, Song-ping Luo. Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion. [J]. Chinese Journal of Integrative Medicine 15(5):353-358(2009)
Liu, F., Luo, Sp. Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion., Chin. J. Integr. Med. 15, 353–358 (2009). https://doi.org/10.1007/s11655-009-0353-z DOI：

Fang Liu, Song-ping Luo. Effect of Chinese herbal treatment on Th1- and Th2-type cytokines, progesterone and β-human chorionic gonadotropin in early pregnant women of threatened abortion. [J]. Chinese Journal of Integrative Medicine 15(5):353-358(2009) DOI： 10.1007/s11655-009-0353-z.

摘要

To study the clinical effects of Prescription Zhuyun-III (助孕3号方

ZYIII) on early pregnant women diagnosed as threatened abortion

and its mechanism in immunity and endocrine by determining serum Th1- and Th2-type cytokines

progesterone

and β-human chorionic gonadotropin (β-HCG). The treatment group comprised 30 early pregnant women diagnosed as threatened abortion of deficiency syndrome of Pi (脾)

Shen (肾)

or both. The control group consisted of 20 normal early pregnant women of similar gestational age. Patients in the treatment group were administered with ZYIII for 4 weeks. Peripheral blood samples were collected pre- and post-treatment from both the treatment and the control groups. Serum Th1-type cytokine [interleukin-2 (IL-2)] and Th2-type cytokine [interleukin-10 (IL-10)] were determined by flow cytometry

and serum progesterone and β-HCG were determined by ELISA. (1) The treatment was effective in 26 and ineffective in 4 patients of the treatment group. Therefore

the cure percentage was 86.67%. (2) In the treatment group before the treatment

IL-2 was significantly higher

IL-10 tended to be less

and the Th1/Th2 balance shifted toward Th1 compared with those in the control group. (3) After the treatment

IL-2 was decreased

IL-10 was increased

and IL-2/IL-10 was decreased. Both progesterone and β-HCG were increased. Changes of progesterone were positively correlated with changes of IL-10

whereas changes of β-HCG were negatively correlated with changes of IL-2. Our study suggests that ZYIII has an evident function of protecting the fetus

and one of its mechanisms is inhibiting the secretion of Th1 cytokines

promoting the secretion of Th2 cytokines

and recovering the pathological shift of the Th1/Th2 balance. The other possible mechanism is increasing serum progesterone and β-HCG concentrations. Moreover

there are some correlations between the above two effects.

Abstract

To study the clinical effects of Prescription Zhuyun-III (助孕3号方

ZYIII) on early pregnant women diagnosed as threatened abortion

and its mechanism in immunity and endocrine by determining serum Th1- and Th2-type cytokines

progesterone

and β-human chorionic gonadotropin (β-HCG). The treatment group comprised 30 early pregnant women diagnosed as threatened abortion of deficiency syndrome of Pi (脾)

Shen (肾)

and serum progesterone and β-HCG were determined by ELISA. (1) The treatment was effective in 26 and ineffective in 4 patients of the treatment group. Therefore

the cure percentage was 86.67%. (2) In the treatment group before the treatment

IL-2 was significantly higher

IL-10 tended to be less

and the Th1/Th2 balance shifted toward Th1 compared with those in the control group. (3) After the treatment

IL-2 was decreased

IL-10 was increased

and IL-2/IL-10 was decreased. Both progesterone and β-HCG were increased. Changes of progesterone were positively correlated with changes of IL-10

whereas changes of β-HCG were negatively correlated with changes of IL-2. Our study suggests that ZYIII has an evident function of protecting the fetus

and one of its mechanisms is inhibiting the secretion of Th1 cytokines

promoting the secretion of Th2 cytokines

and recovering the pathological shift of the Th1/Th2 balance. The other possible mechanism is increasing serum progesterone and β-HCG concentrations. Moreover

there are some correlations between the above two effects.

关键词

Threatened AbortionPrescription Zhuyun-IIITh1- and Th2-type cytokinesProgesteroneβ-human chorionic gonadotropin

Keywords

Threatened AbortionPrescription Zhuyun-IIITh1- and Th2-type cytokinesProgesteroneβ-human chorionic gonadotropin

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Institute of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

Institute of Reproductive Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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