Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits

Lu Zhang; Yue-rong Jiang; Chun-yu Guo; Cai-feng Wu; Ke-ji Chen; Hui-jun Yin

doi:10.1007/s11655-009-0359-6

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Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits

Updated：2021-08-27

- Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits
- Chinese Journal of Integrative Medicine Vol. 15, Issue 5, Pages: 359-364(2009)
- Affiliations：
  
  Center of Cardio-vascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Major State Basic Research Development Program of China (973 Program, No. 2006CB504803)
- DOI：10.1007/s11655-009-0359-6
  CLC：
- Published：2009，
  
  Published Online：3 October 2009，
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Zhang, L., Jiang, Yr., Guo, Cy. et al. Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits., Chin. J. Integr. Med. 15, 359–364 (2009). https://doi.org/10.1007/s11655-009-0359-6

Lu Zhang, Yue-rong Jiang, Chun-yu Guo, et al. Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits. [J]. Chinese Journal of Integrative Medicine 15(5):359-364(2009)
Zhang, L., Jiang, Yr., Guo, Cy. et al. Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits., Chin. J. Integr. Med. 15, 359–364 (2009). https://doi.org/10.1007/s11655-009-0359-6 DOI：

Lu Zhang, Yue-rong Jiang, Chun-yu Guo, et al. Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits. [J]. Chinese Journal of Integrative Medicine 15(5):359-364(2009) DOI： 10.1007/s11655-009-0359-6.

摘要

To investigate the effects and mechanism of the active components of Red Paeonia and Rhizoma chuanxiong (Xiongshao Capsule

芎芍胶囊

XSC) on angiogenesis in atherosclerosis plaque in rabbits. Fifty New Zealand rabbits were randomly divided into the normal group

the model group

and the three medicated groups treated respectively with Simvastatin (2.5 mg/kg per day)

low-dose (0.24 g/kg per day) and high-dose (0.48 g/kg per day) XSC

10 in each group. Rabbits in the normal group were fed with regular diet. To those in the other four groups

high fat diet was given

and a balloon angioplasty was performed two weeks later to establish abdominal aortic atherosclerosis model. Then

the model rabbits were fed continuously with high fat diet

and to those in the medicated groups

the testing drugs were added in the forage correspondingly for 6 successive weeks. Levels of blood lipids were measured at the end of the experiment. Meantime

serum levels of high sensitivity C-reactive protein (hsCRP) and tumor necrosis factor α (TNF-α) were detected with enzyme-linked immunoassay; the plaque area (PA)

cross-sectional vascular area (CVA) and correcting plaque area (PA/CVA) were determined quantitatively using imaging software; and the protein expression of vascular endothelial growth factor (VEGF) and factor VIII related antigen (FVIIIRAg) in plaque was detected using immunohistochemical method. As compared with the model group

the content of total cholesterol (TC) in the three medicated groups

and contents of triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the Simvastatin group were lower to various extents (P<0.05

P<0.01). The serum level of hsCRP in all modeled rabbits was higher than that in the normal group

but in the three treated groups it was significantly lower than that in the model group (P<0.05

P<0.01). Expressions of VEGF and FVIIIRAg

as well as PA/CVA in the three medicated groups were significantly lower than those in the model control group (P<0.05

P<0.01). The active components of Red Paeonia and Rhizoma chuanxiong have definite effects in delaying the genesis and development of atherosclerosis

its mechanism might be related with the inhibition on angiogenesis in plaque

and also with its actions of lipo-metabolism regulation and anti-inflammation.

Abstract

To investigate the effects and mechanism of the active components of Red Paeonia and Rhizoma chuanxiong (Xiongshao Capsule

芎芍胶囊

XSC) on angiogenesis in atherosclerosis plaque in rabbits. Fifty New Zealand rabbits were randomly divided into the normal group

the model group

and the three medicated groups treated respectively with Simvastatin (2.5 mg/kg per day)

low-dose (0.24 g/kg per day) and high-dose (0.48 g/kg per day) XSC

10 in each group. Rabbits in the normal group were fed with regular diet. To those in the other four groups

high fat diet was given

and a balloon angioplasty was performed two weeks later to establish abdominal aortic atherosclerosis model. Then

the model rabbits were fed continuously with high fat diet

and to those in the medicated groups

the testing drugs were added in the forage correspondingly for 6 successive weeks. Levels of blood lipids were measured at the end of the experiment. Meantime

serum levels of high sensitivity C-reactive protein (hsCRP) and tumor necrosis factor α (TNF-α) were detected with enzyme-linked immunoassay; the plaque area (PA)

the content of total cholesterol (TC) in the three medicated groups

and contents of triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) in the Simvastatin group were lower to various extents (P<0.05

P<0.01). The serum level of hsCRP in all modeled rabbits was higher than that in the normal group

but in the three treated groups it was significantly lower than that in the model group (P<0.05

P<0.01). Expressions of VEGF and FVIIIRAg

as well as PA/CVA in the three medicated groups were significantly lower than those in the model control group (P<0.05

P<0.01). The active components of Red Paeonia and Rhizoma chuanxiong have definite effects in delaying the genesis and development of atherosclerosis

its mechanism might be related with the inhibition on angiogenesis in plaque

and also with its actions of lipo-metabolism regulation and anti-inflammation.

关键词

atherosclerosistotal paeony glycosideChuanxiongolsangiogenesisinflammation

Keywords

atherosclerosistotal paeony glycosideChuanxiongolsangiogenesisinflammation

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Department of Cardiology, First Affiliated Hospital of Zhejiang Chinese Medical University

Lab, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou

Department of Traditional Chinese Medicine, Shanghai No. 6 People’s Hospital, Affiliated to Shanghai Jiaotong University

Integrative Hospital, College of Chinese Medicine, Southern Medical University

Zhujiang Hospital, Southern Medical University

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