Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats

En-yuan Tu; Ya-guang Zhou; Zhao-hua Wang; Qian-sheng Liang; Guang-tian Yang

doi:10.1007/s11655-009-0365-8

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Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats

Updated：2021-08-27

- Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats
- Chinese Journal of Integrative Medicine Vol. 15, Issue 5, Pages: 365-370(2009)
- Affiliations：
  
  Department of Emergency, Tongji Hospital, Tongji College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30500657)
- DOI：10.1007/s11655-009-0365-8
  CLC：
- Published：2009，
  
  Published Online：3 October 2009，
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Tu, Ey., Zhou, Yg., Wang, Zh. et al. Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats., Chin. J. Integr. Med. 15, 365–370 (2009). https://doi.org/10.1007/s11655-009-0365-8

En-yuan Tu, Ya-guang Zhou, Zhao-hua Wang, et al. Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats. [J]. Chinese Journal of Integrative Medicine 15(5):365-370(2009)
Tu, Ey., Zhou, Yg., Wang, Zh. et al. Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats., Chin. J. Integr. Med. 15, 365–370 (2009). https://doi.org/10.1007/s11655-009-0365-8 DOI：

En-yuan Tu, Ya-guang Zhou, Zhao-hua Wang, et al. Effects of tanshinone II A on the myocardial hypertrophy signal transduction system protein kinase B in rats. [J]. Chinese Journal of Integrative Medicine 15(5):365-370(2009) DOI： 10.1007/s11655-009-0365-8.

摘要

To study the effect of tanshinone II A on the cell signal transduction system protein kinase B (Akt) in rats with hypertrophy of the myocardium induced by partial constriction of the thoracic aorta. Rat models of myocardial hypertrophy were established by the thoracic aorta partial constriction method. Forty-eight rats were randomly divided into the sham-operative group

the model group

the valsartan treatment group

and the low-

medium-

and high-dose tanshinone treatment groups. The heart mass index (HMI)

left ventricular mass index (LVMI)

ejection fraction (EF)

left ventricular posterior wall (LVPW)

and interventricular septal thickness (IVS) were detected by high-frequency ultrasonography. The myocardial fiber diameter (MFD) was detected by HE staining

and the contents of p-Akt and p-Gsk3β in the myocardium were detected by Western blot. Compared with the sham-operative group

the levels of HMI

LVMI

LVPW

IVS

and MFD were increased respectively in the other groups (P<0.05); the contents of p-Akt and p-Gsk3β were also increased in the other groups. Compared with the model group

the levels of HMI

LVMI

LVPW

IVS

and MFD were decreased respectively in all treatment groups (P<0.05); the contents of p-Akt and p-Gsk3β were decreased in all treatment groups as well. There was no significant difference

however

among the low-

medium-

and high-dose tanshinone treatment groups and the valsartan treatment group (P>0.05). Tanshinone II A can prevent myocardial hypertrophy by its action on the protein kinase B (Akt) signaling pathway.

Abstract

the model group

the valsartan treatment group

and the low-

medium-

and high-dose tanshinone treatment groups. The heart mass index (HMI)

left ventricular mass index (LVMI)

ejection fraction (EF)

left ventricular posterior wall (LVPW)

and interventricular septal thickness (IVS) were detected by high-frequency ultrasonography. The myocardial fiber diameter (MFD) was detected by HE staining

and the contents of p-Akt and p-Gsk3β in the myocardium were detected by Western blot. Compared with the sham-operative group

the levels of HMI

LVMI

LVPW

IVS

and MFD were increased respectively in the other groups (P<0.05); the contents of p-Akt and p-Gsk3β were also increased in the other groups. Compared with the model group

the levels of HMI

LVMI

LVPW

IVS

and MFD were decreased respectively in all treatment groups (P<0.05); the contents of p-Akt and p-Gsk3β were decreased in all treatment groups as well. There was no significant difference

however

among the low-

medium-

and high-dose tanshinone treatment groups and the valsartan treatment group (P>0.05). Tanshinone II A can prevent myocardial hypertrophy by its action on the protein kinase B (Akt) signaling pathway.

关键词

tanshinone II Amyocardial hypertrophyratprotein kinase Bthoracic aorta coarctation

Keywords

tanshinone II Amyocardial hypertrophyratprotein kinase Bthoracic aorta coarctation

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