FOLLOWUS
New achievements in ginseng research and its future prospects
- Chinese Journal of Integrative Medicine Vol. 15, Issue 6, Pages: 403-408(2009)
- Affiliations：
Institute of Material Medica, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. C03030703)
DOI：10.1007/s11655-009-0403-6
CLC：Published：2009，
Published Online：18 January 2010，
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Chu, Sf., Zhang, Jt. New achievements in ginseng research and its future prospects., Chin. J. Integr. Med. 15, 403–408 (2009). https://doi.org/10.1007/s11655-009-0403-6
Shi-feng Chu, Jun-tian Zhang. New achievements in ginseng research and its future prospects. [J]. Chinese Journal of Integrative Medicine 15(6):403-408(2009)
Chu, Sf., Zhang, Jt. New achievements in ginseng research and its future prospects., Chin. J. Integr. Med. 15, 403–408 (2009). https://doi.org/10.1007/s11655-009-0403-6 DOI：
Shi-feng Chu, Jun-tian Zhang. New achievements in ginseng research and its future prospects. [J]. Chinese Journal of Integrative Medicine 15(6):403-408(2009) DOI： 10.1007/s11655-009-0403-6.
摘要
In recent decades
scientists in Asian and Western countries have been paying great attention to ginseng research. Today
more than 200 ginsenosides and non-saponin constituents have been isolated and identified. Ginsenosides show biological activities only after being deglycosylated by intestinal bacteria. Aglycone protopanaxadiol and protopanaxatriol show the highest bioactivities. According to literature
the noticeable action of ginseng is that of delaying aging and especially increasing the nootropic effect
and it was found for the first time that Rg1 could increase hippocampal neurogenesis in vitro and in vivo under physiological and pathological circumstances. This is one of primary mechanisms underlying many of its pharmacological actions on the central nervous system. Rg1 was further shown to improve learning and memory in normal rats and mice. The nootropic signaling pathway has also been carried out in normal rats
and the Rg1-induced signaling pathway is similar to the memory formation that occurs in mammals
suggesting that Rg1 may have a potential effect in increasing intellectual capacity in normal people. Comparisons of chemical structures and pharmacologic functions between Panax ginseng and Panax quiquefolium were carried out by many scientists. The conclusion is that each has its own characteristics. There is no superiority or inferiority to the other.
Abstract
In recent decades
scientists in Asian and Western countries have been paying great attention to ginseng research. Today
more than 200 ginsenosides and non-saponin constituents have been isolated and identified. Ginsenosides show biological activities only after being deglycosylated by intestinal bacteria. Aglycone protopanaxadiol and protopanaxatriol show the highest bioactivities. According to literature
the noticeable action of ginseng is that of delaying aging and especially increasing the nootropic effect
and it was found for the first time that Rg1 could increase hippocampal neurogenesis in vitro and in vivo under physiological and pathological circumstances. This is one of primary mechanisms underlying many of its pharmacological actions on the central nervous system. Rg1 was further shown to improve learning and memory in normal rats and mice. The nootropic signaling pathway has also been carried out in normal rats
and the Rg1-induced signaling pathway is similar to the memory formation that occurs in mammals
suggesting that Rg1 may have a potential effect in increasing intellectual capacity in normal people. Comparisons of chemical structures and pharmacologic functions between Panax ginseng and Panax quiquefolium were carried out by many scientists. The conclusion is that each has its own characteristics. There is no superiority or inferiority to the other.
关键词
Panax GinsengPanax quiquefoliumnootropicsneural plasticityneurogenesisangiogenesissignaling pathway
Keywords
Panax GinsengPanax quiquefoliumnootropicsneural plasticityneurogenesisangiogenesissignaling pathway
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