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Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats
- Chinese Journal of Integrative Medicine Vol. 15, Issue 6, Pages: 448-453(2009)
- Affiliations：
1. Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, Madhya Pradesh,India
2. Department of Chemistry, University of Natural and Applied Life Sciences,Vienna,Austria
- Author bio：
- Funds：
DOI：10.1007/s11655-009-0448-6
CLC：Published：2009，
Published Online：18 January 2010，
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Thakur, M., Bhargava, S., Praznik, W. et al. Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats., Chin. J. Integr. Med. 15, 448–453 (2009). https://doi.org/10.1007/s11655-009-0448-6
Mayank Thakur, Shilpi Bhargava, Werner Praznik, et al. Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats. [J]. Chinese Journal of Integrative Medicine 15(6):448-453(2009)
Thakur, M., Bhargava, S., Praznik, W. et al. Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats., Chin. J. Integr. Med. 15, 448–453 (2009). https://doi.org/10.1007/s11655-009-0448-6 DOI：
Mayank Thakur, Shilpi Bhargava, Werner Praznik, et al. Effect of Chlorophytum Borivilianum Santapau and Fernandes on sexual dysfunction in hyperglycemic male rats. [J]. Chinese Journal of Integrative Medicine 15(6):448-453(2009) DOI： 10.1007/s11655-009-0448-6.
摘要
To investigate the effects of Chlorophytum borivilianum (CB) on sexual dysfunction
loss of body weight
and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan. Wistar strain male albino rats were divided into five groups of six animals each: the control group (2% polyvinylpyrollidone solution)
the streptozotocin control group (50 mg/kg)
the alloxan control group (100 mg/kg)
the streptozotocin + CB treated group (200 mg/kg)
and the alloxan + CB treated group (200 mg/kg). Only after confirming the induction of diabetes
the animals of test groups were treated with CB. The sexual behavior of male rats of in presence of female rat in a special cage was recorded. The effects of induced diabetes in control groups and on simultaneous extract treatment in CB treated groups were tested for sexual parameters. The parameters evaluated included mount
ejaculation
and intromission latencies/frequencies
hesitation time
and penile erection index. Parallel to this
using a separate set of similarly treated animals
the influence of diabetes and CB treatment on anabolism and weight of secondary sexual organs were determined on day 0 and day 28 of the treatment. CB extract treatment ameliorated the diabetes-induced dysfunction at 200 mg/kg dose. There was very low weight loss (P<0.05) in CB-treated animals as compared to the diabetic control. There was a very high latency time (P<0.05) in the diabetic animals
whereas the latency time was very low in CB-treated animals. Mount
intromission
and ejaculation frequencies were very high (P<0.01) in CB-treated animals
while streptozotocin and alloxan groups animals had a very significantly lower sexual behavior (P<0.05) compared to the normo-glycemic control group animals. CB can significantly ameliorate diabetes-induced sexual dysfunction. Polysaccharide and saponin-rich aqueous extract appears to have the most suitable effects on diabetes and its associated effects on sexual functionality.
Abstract
To investigate the effects of Chlorophytum borivilianum (CB) on sexual dysfunction
loss of body weight
and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan. Wistar strain male albino rats were divided into five groups of six animals each: the control group (2% polyvinylpyrollidone solution)
the streptozotocin control group (50 mg/kg)
the alloxan control group (100 mg/kg)
the streptozotocin + CB treated group (200 mg/kg)
and the alloxan + CB treated group (200 mg/kg). Only after confirming the induction of diabetes
the animals of test groups were treated with CB. The sexual behavior of male rats of in presence of female rat in a special cage was recorded. The effects of induced diabetes in control groups and on simultaneous extract treatment in CB treated groups were tested for sexual parameters. The parameters evaluated included mount
ejaculation
and intromission latencies/frequencies
hesitation time
and penile erection index. Parallel to this
using a separate set of similarly treated animals
the influence of diabetes and CB treatment on anabolism and weight of secondary sexual organs were determined on day 0 and day 28 of the treatment. CB extract treatment ameliorated the diabetes-induced dysfunction at 200 mg/kg dose. There was very low weight loss (P<0.05) in CB-treated animals as compared to the diabetic control. There was a very high latency time (P<0.05) in the diabetic animals
whereas the latency time was very low in CB-treated animals. Mount
intromission
and ejaculation frequencies were very high (P<0.01) in CB-treated animals
while streptozotocin and alloxan groups animals had a very significantly lower sexual behavior (P<0.05) compared to the normo-glycemic control group animals. CB can significantly ameliorate diabetes-induced sexual dysfunction. Polysaccharide and saponin-rich aqueous extract appears to have the most suitable effects on diabetes and its associated effects on sexual functionality.
关键词
Ayurvedic RasayanaChlorophytum borivilianumdiabetes induced sexual dysfunctionSafed Musli
Keywords
Ayurvedic RasayanaChlorophytum borivilianumdiabetes induced sexual dysfunctionSafed Musli
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