The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation

Dong Gao; Li-ya Wu; Yu-huan Jiao; Wen-yuan Chen; Yan Chen; Ted J. Kaptchuk; Bo Lu; Jun Song; Ke-ji Chen

doi:10.1007/s11655-010-0050-y

Your Location：

Home >

Browse articles >

The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation

Updated：2021-08-27

- The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation
- Chinese Journal of Integrative Medicine Vol. 16, Issue 1, Pages: 50-53(2010)
- Affiliations：
  
  1. Department of Integrative Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Experimental Research Center, China Academy of Chinese Medical Sciences,Beijing,China
  3. Harvard Medical School,Boston,USA
  4. Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30772877);Basic Research Fund of China Academy of Chinese Medical Sciences (No. ZZ2006039);Fujian Academy of Integrative Medicine Foundation (No. 3000-905010805)
- DOI：10.1007/s11655-010-0050-y
  CLC：
- Published：2010，
  
  Published Online：4 February 2010，
Scan for full text
Gao, D., Wu, Ly., Jiao, Yh. et al. The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation., Chin. J. Integr. Med. 16, 50–53 (2010). https://doi.org/10.1007/s11655-010-0050-y

Dong Gao, Li-ya Wu, Yu-huan Jiao, et al. The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation. [J]. Chinese Journal of Integrative Medicine 16(1):50-53(2010)
Gao, D., Wu, Ly., Jiao, Yh. et al. The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation., Chin. J. Integr. Med. 16, 50–53 (2010). https://doi.org/10.1007/s11655-010-0050-y DOI：

Dong Gao, Li-ya Wu, Yu-huan Jiao, et al. The effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on in vitro endothelial progenitor cell tube formation. [J]. Chinese Journal of Integrative Medicine 16(1):50-53(2010) DOI： 10.1007/s11655-010-0050-y.

摘要

To observe the effect of Xuefu Zhuyu Decoction (血府逐瘀汤)-containing serum (XFZYD-CS) on endothelial progenitor cell (EPC) tube formation in vitro. Mononuclear cells from rat bone marrow were prepared in a Ficoll density gradient centrifuge. EPCs were separated by the differential attachment method

and observed with inverted microscope for the effect of XFZYD-CS on EPC tube formation. After one day

EPCs exposed to the serum containing 5%

10% and 15% XFZYD-CS formed typical tubes or vessel networks. The tube formation time was two days ahead of the control group and the size of most tubes in the serum groups was smaller than in the control group. XFZYD-CS could induce EPC angiogenesis and hasten tube formation

especially in capillary vessels. The study provides experimental evidence for the plausibility of Xuefu Zhuyu Decoction in the treatment of ischemic diseases.

Abstract

and observed with inverted microscope for the effect of XFZYD-CS on EPC tube formation. After one day

EPCs exposed to the serum containing 5%

especially in capillary vessels. The study provides experimental evidence for the plausibility of Xuefu Zhuyu Decoction in the treatment of ischemic diseases.

关键词

Xuefu Zhuyu Decoctionendothelial progenitor cellstube formation

Keywords

Xuefu Zhuyu Decoctionendothelial progenitor cellstube formation

references

Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative endothelial progenitor cells for angiogenesis. Science 1997;275:964–967.

Asahara T, Kawamoto A. Endothelial progenitor cells for postnatal vasculogenesis. Am J Physiol Cell Physiol 2004;287:572–579.

Urbich C, Dimmeler S. Endothelial progenitor cells: characterization and role in vascular biology. Circ Res 2004;95:343–353.

Eguchi M, Masuda H, Asahara T. Endothelial progenitor cells for postnatal vasculogenesis. Clin Exp Nephrol 2007;11:18–25.

Kawamoto A, Asahara T. Role of progenitor endothelial cells in cardiovascular disease and upcoming therapies. Catheter Cardiovasc Interv 2007;70:477–484.

Zhang M, Zhou SH, Li XP, Shen XQ, Fang ZF. A novel hypothesis of atherosclerosis: EPCs-mediated repair-toinjury. Med Hypotheses 2008;70:838–841.

Edelberg JM, Tang L, Hattori K, Lyden D, Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res 2002;90:E89–E93.

Schmeisser A, Garlichs CD, Zhang H, Eskafi S, Graffy C, Ludwig J, et al. Monocytes coexpress endothelial and macrophagocytic lineage makers and form cordlike structures in matrigel under angiogenic conditions. Cardiovasc Res 2001;49:671–680.

Fernandez Pujol B, Lucibello FC, Gehling UM, Lindemann K, Weidner N, Zuzarte ML, et al. Endothelial-like cells derived from CD14 positive monocytes. Differentiation 2000;65:287–300.

Gao D, Lin JM, Zheng LP, Lin W, Chen XZ, Song J, et al. Experimental study on effect of Xuefu Zhuyu decoction on HSC from mouse marrow. Chin J Integr Tradit West Med (Chin) 2007;27:527–530.

Gao D, Song J, Hu J, Lin JM, Zheng LP, Cai J, et al. Angiogenesis promoting effects of Chinese herbal medicine for activating blood circulation to remove stasis on chick embryo chorio-allantoic membrane. Chin J Integr Tradit West Med (Chin) 2005;25:912–915.

Gao D, Lin W, Zheng LP, Lin JM, Chen XZ, Song J, et al. Experimental study on effect of Xuefu Zhuyu decoction on EPC migrating from rat marrow. Chin J Integr Med Cardio/Cerebrovasc Dis (Chin) 2007;5:829–831.

FULL TEXT LINK

More>

Views

379

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

A microarray analysis of angiogenesis modulation effect of Xuefu Zhuyu Decoction (血府逐瘀汤) on endothelial cells

Chinese medicines and bioactive compounds for treatment of stroke

In Vitro Angiogenesis Effect of Xuefu Zhuyu Decoction (血府逐瘀汤) and Vascular Endothelial Growth Factor: A Comparison Study

Berberine-Promoted CXCR4 Expression Accelerates Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Persons with Prehypertension

Related Author

No data

Related Institution

Fujian Academy of Integrative Medicine

Graduate Institute of Medical Sciences, Taipei Medical University, Taipei

Department of Biotechnology, Periyar Maniammai University, Thanjavur, Tamil Nadu

Department of Pharmacology, Taipei Medical University, Taipei

College of Integrative Medicine, Fujian University of Traditional Chinese Medicine

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰