Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression

Guo-lin Wu; Li Zhang; Tian-yi Li; Jiu Chen; Guo-you Yu; Jian-ping Li

doi:10.1007/s11655-010-0109-9

Your Location：

Home >

Browse articles >

Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression

Updated：2021-08-27

- Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression
- Chinese Journal of Integrative Medicine Vol. 16, Issue 2, Pages: 109-113(2010)
- Affiliations：
  
  1. The First Affiliated Hospital, College of Medicine, Zhejiang University,Hangzhou,China
  2. Center for Drug Reevaluation, State Food and Drug Administration,Beijing,China
  3. Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0109-9
  CLC：
- Published：2010，
  
  Published Online：16 May 2010，
Scan for full text
Wu, Gl., Zhang, L., Li, Ty. et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression., Chin. J. Integr. Med. 16, 109–113 (2010). https://doi.org/10.1007/s11655-010-0109-9

Guo-lin Wu, Li Zhang, Tian-yi Li, et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression. [J]. Chinese Journal of Integrative Medicine 16(2):109-113(2010)
Wu, Gl., Zhang, L., Li, Ty. et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression., Chin. J. Integr. Med. 16, 109–113 (2010). https://doi.org/10.1007/s11655-010-0109-9 DOI：

Guo-lin Wu, Li Zhang, Tian-yi Li, et al. Short-term effect of combined therapy with Jinlong Capsule (金龙胶囊) and transcatheter arterial chemoembolization on patients with primary hepatic carcinoma and its influence on serum osteopontin expression. [J]. Chinese Journal of Integrative Medicine 16(2):109-113(2010) DOI： 10.1007/s11655-010-0109-9.

摘要

To observe the clinical combination effect of Jinlong Capsule (金龙胶囊

JLC) and transcatheter arterial chemoembolization (TACE) on the patients with primary hepatic carcinoma (PHC) and JLC’ s influence on serum osteopontin (OPN) expression and elucidate the correlation between the serum OPN level and curative effect of JLC and TACE. A total of 98 patients with PHC were observed in a randomized controlled trial (RCT). They were assigned to the Chinese medicine (CM) group (53 patients who were treated with TACE and JLC) and the intervention group (45 patients who were treated with TACE only). The serum OPN levels were measured before and after treatment by quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Forty healthy people were assigned to the control group. The clinical efficacy was observed and Karnofsky score (KPS) was graded. The clinical efficacy of the CM group (60.38%) was better than that of the intervention group (40.00 %)

and the KPS (84.35±12.19) was higher than the intervention group (69.86± 11.58) (P<0.05). The serum OPN levels before and after treatment in the patients with PHC were significantly elevated compared with those in the control group (P<0.01). After treatment

the OPN levels in CM group (117.69 <±78.50) were significantly lower compared with those in intervention group (151.09±83.90

P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment

and the level of OPN in the CM group was lower than the intervention group (P<0.05). The short-term clinical efficacy and the quality of life of patients with PHC can be improved by combining JLC with TACE. The serum OPN levels in PHC patients can reflect the curative effect of treatment and the prognosis of the disease.

Abstract

To observe the clinical combination effect of Jinlong Capsule (金龙胶囊

the OPN levels in CM group (117.69 <±78.50) were significantly lower compared with those in intervention group (151.09±83.90

P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment

关键词

Jinlong Capsuletranscatheter arterial chemoembolizationprimary hepatic carcinomaosteopontinclinical efficacy

Keywords

Jinlong Capsuletranscatheter arterial chemoembolizationprimary hepatic carcinomaosteopontinclinical efficacy

references

The Hepatoma Board of Chinese Anti-cancer Association. The clinical diagnosis and standard of staging of primary hepatic carcinoma. Chin J Hepatol (Chin) 2001;9:324–325.

Sun Y, ed. Medical oncology. Beijing: People’s Medical Publishing House, 2001:995–996.

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92: 205–216.

Liu YY, Lai JX. The progress of hepatoma treatment. J Clin Surg (Chin) 2007;15:2–7.

Poon RT, Fan ST, Tsang FH, Wong J. Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon’s perspective. Ann Surg 2002; 235:466–486.

Su XK, Zhou WS, Xu FB, Wang FJ, Zhao TQ, Lin YS, et al. The clinical observation of combination treatment of traditional Chinese medcine and TACE of primary hepatic carcinoma in 219 patients. J Tradit Chin Med (Chin) 2004; 45:434–436.

Senger DR, Perruzzi CA. Secreted phosphoprotein markers for neoplastic transformation of human epithelial and fibroblastic cells. Cancer Res 1985;45:5818–5823.

Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers AF, et al. Correlation of osteopontin protein. Clin Cancer Res 2004;10:184–190.

Gotoh M, Sakamoto M, Kanetaka K, Chuuma M, Hirohashi S. Overexpression of osteopontin in hepatocellular carcinoma. Pathol Int 2002;52:19–24.

Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, et al. Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003;9:416–423.

FULL TEXT LINK

More>

Views

395

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Preventive effects of Jiedu Granules (解毒颗粒) combined with Cinobufacini Injection (华蟾素注射液) versus transcatheter arterial chemoembolization in post-surgical patients with hepatocellular carcinoma: A case-control trial

Effects of Er’zhi Tiangui Granule (二至天癸颗粒) on sequential expressions of integrin β 3 and its ligand osteopontin in mouse endometrium during controlled ovarian hyperstimulation

Application and assessment of Chinese arsenic drugs in treating malignant hematopathy in China

Clinical observation on the efficacy of Xiaoshui decoction (消水方) combined with intrapleural perfusion of cisplatin in treating malignant pleural effusion

Relationship between abnormal characteristics of sublingual collateral and portal vein hemodynamic changes in patients with primary hepatic carcinoma

Related Author

No data

Related Institution

Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University

Reproductive Center, the Affiliated Hospital of Shandong, University of Traditional Chinese Medicine

Basic Medicine Research Institution, Shandong Academy of Medical Sciences

Clinical College, Shandong University of Traditional Chinese Medicine

Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰