Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia

Li-qi Qian; Bin Wang; Jing-yu Niu; Shan Gao; Dan-yang Zhao

doi:10.1007/s11655-010-0124-x

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Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia

Updated：2021-08-27

- Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia
- Chinese Journal of Integrative Medicine Vol. 16, Issue 2, Pages: 124-130(2010)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, First Affiliated Hospital of General Hospital of PLA,Beijing,China
  2. General Hospital of Air Force,Beijing,China
  3. Jingxi Area of Beijing Chaoyang Hospital,Beijing,China
  4. Beijing Yongding Road Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0124-x
  CLC：
- Published：2010，
  
  Published Online：16 May 2010，
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Qian, Lq., Wang, B., Niu, Jy. et al. Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia., Chin. J. Integr. Med. 16, 124–130 (2010). https://doi.org/10.1007/s11655-010-0124-x

Li-qi Qian, Bin Wang, Jing-yu Niu, et al. Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 16(2):124-130(2010)
Qian, Lq., Wang, B., Niu, Jy. et al. Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia., Chin. J. Integr. Med. 16, 124–130 (2010). https://doi.org/10.1007/s11655-010-0124-x DOI：

Li-qi Qian, Bin Wang, Jing-yu Niu, et al. Assessment of the clinical effect of Chinese medicine therapy combined with psychological intervention for treatment of patients of peri-menopausal syndrome complicated with hyperlipidemia. [J]. Chinese Journal of Integrative Medicine 16(2):124-130(2010) DOI： 10.1007/s11655-010-0124-x.

摘要

To observe the effect of Chinese medicine therapy combined with psychological intervention (combined therapy) on the clinical symptoms and levels of blood lipids and sex hormones of patients of peri-menopausal syndrome complicated with hyperlipidemia. With the use of a randomizing digital table method

185 patients that fit the registration standard were randomly assigned to three groups. The 59 cases in Group A were treated with two Chinese patents

Kunbao Pill (坤宝丸) and Modified Xiaoyao Pill (加味逍遥丸); the 63 in Group B received psychological intervention alone; and the 63 in Group C were treated with both (the combined therapy)

with the treatment course for all six months. The items of observation included: (1) scoring by SCL-90 on eight factors and seven symptoms; (2) scoring on Chinese medicine symptoms by Kupermann scale

including anxiety and bad temper

scorching sense ation with sweating

dizziness

tinnitus

soreness and weakness of the loin and knees

palpitation

insomnia

lassitude

weakness

and hyposexuality; (3) blood contents of total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol (LDL-C)

apoprotein AI (ApoAI) and B (ApoB); (4) levels of sex hormones

including estradiol (E2)

progesterone (P)

pituitary prolactin (PRL)

follicular stimulating hormone (FSH)

and)

luteinzing hormone (LH) in some randomly selected patients; (5) adverse reaction; and (6) one-year follow-up study on long-term effect. A total of 21 patients (6

and 7 cases in Groups A

and C

respectively) dropped out; the drop-out rate was insignificant among groups. (1) The markedly effective rates in Group A

and C were 26.42% (14/53)

18.18% (10/55)

and 53.57% (30/56)

respectively

and the total effective rates in them were 64.15% (34/53)

50.91% (28/55)

and 87.50% (49/56)

respectively

suggesting the therapeutic efficacy in Group C was significantly better than that in Groups A and B (P<0.01). (2) SCL-90 scoring showed that the total scores decreased significantly after treatment in Group C (P<0.01)

but remained unchanged in Groups A and B (P>0.05). (3) Scoring on Chinese medicine symptoms showed the same results as shown by SCL-90 scoring in terms of total scores and individual symptoms

except that menstrual disorder and amenorrhea were unchanged in all three groups (P>0.05). (4) Levels of HDL-C

ApoAI

and E2 increased and those of TG

LDL-C

ApoB

FSH

and LH decreased after treatment in Group C

reaching near normal levels; similar trends of blood lipids were shown in Group A

but the level of sex hormones was unchanged. In Group B all the above-mentioned indices were unchanged (P>0.05). (5) A one-year follow-up study showed the markedly effective rate and the total effective rate in Group C were higher than those in the other two groups respectively (P<0.01). (6) No adverse reaction was found. Chinese medicine therapy combined with psychological intervention could not only improve the nervous symptoms

but also regulate the blood levels of lipids and sex hormones in patients of peri-menopausal syndrome complicated with hyperlipidemia.

Abstract

185 patients that fit the registration standard were randomly assigned to three groups. The 59 cases in Group A were treated with two Chinese patents

Kunbao Pill (坤宝丸) and Modified Xiaoyao Pill (加味逍遥丸); the 63 in Group B received psychological intervention alone; and the 63 in Group C were treated with both (the combined therapy)

with the treatment course for all six months. The items of observation included: (1) scoring by SCL-90 on eight factors and seven symptoms; (2) scoring on Chinese medicine symptoms by Kupermann scale

including anxiety and bad temper

scorching sense ation with sweating

dizziness

tinnitus

soreness and weakness of the loin and knees

palpitation

insomnia

lassitude

weakness

and hyposexuality; (3) blood contents of total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein cholesterol (HDL-C)

low-density lipoprotein cholesterol (LDL-C)

apoprotein AI (ApoAI) and B (ApoB); (4) levels of sex hormones

including estradiol (E2)

progesterone (P)

pituitary prolactin (PRL)

follicular stimulating hormone (FSH)

and)

luteinzing hormone (LH) in some randomly selected patients; (5) adverse reaction; and (6) one-year follow-up study on long-term effect. A total of 21 patients (6

and 7 cases in Groups A

and C

respectively) dropped out; the drop-out rate was insignificant among groups. (1) The markedly effective rates in Group A

and C were 26.42% (14/53)

18.18% (10/55)

and 53.57% (30/56)

respectively

and the total effective rates in them were 64.15% (34/53)

50.91% (28/55)

and 87.50% (49/56)

respectively

but remained unchanged in Groups A and B (P>0.05). (3) Scoring on Chinese medicine symptoms showed the same results as shown by SCL-90 scoring in terms of total scores and individual symptoms

except that menstrual disorder and amenorrhea were unchanged in all three groups (P>0.05). (4) Levels of HDL-C

ApoAI

and E2 increased and those of TG

LDL-C

ApoB

FSH

and LH decreased after treatment in Group C

reaching near normal levels; similar trends of blood lipids were shown in Group A

but also regulate the blood levels of lipids and sex hormones in patients of peri-menopausal syndrome complicated with hyperlipidemia.

关键词

Chinese medicine therapypsychological interventionperi-menopausal syndromeblood lipidsex hormone

Keywords

Chinese medicine therapypsychological interventionperi-menopausal syndromeblood lipidsex hormone

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