Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity

Xiao Li; Ping Jiang; Chang-geng Fu

doi:10.1007/s11655-010-0138-4

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Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity

Updated：2021-08-27

- Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity
- Chinese Journal of Integrative Medicine Vol. 16, Issue 2, Pages: 138-144(2010)
- Affiliations：
  
  1. Internal Medical Department, Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Jinan,China
  2. Doctorial Graduate Student of Beijing University of Chinese Medicine,Beijing,China,2008
- Author bio：
- Funds：
  
  Supported by Shandong Provincial Science and Technology Development Program of Traditional Chinese Medicine (No. 2007-008)
- DOI：10.1007/s11655-010-0138-4
  CLC：
- Published：2010，
  
  Published Online：16 May 2010，
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Li, X., Jiang, P. & Fu, Cg. Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity., Chin. J. Integr. Med. 16, 138–144 (2010). https://doi.org/10.1007/s11655-010-0138-4

Xiao Li, Ping Jiang, Chang-geng Fu. Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity. [J]. Chinese Journal of Integrative Medicine 16(2):138-144(2010)
Li, X., Jiang, P. & Fu, Cg. Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity., Chin. J. Integr. Med. 16, 138–144 (2010). https://doi.org/10.1007/s11655-010-0138-4 DOI：

Xiao Li, Ping Jiang, Chang-geng Fu. Preliminary comparative study on the effect of different chinese drugs for strengthening Pi (脾) in antagonizing diet induced obesity. [J]. Chinese Journal of Integrative Medicine 16(2):138-144(2010) DOI： 10.1007/s11655-010-0138-4.

摘要

To observe the difference in fatty degree

glucose-lipid disorder and adipose-hormones between diet induced obesity (DIO) rats and diet induced obesity resistance (DIO-R) rats

and to explore the effect and acting mechanism of Chinese drugs for strengthening Pi (脾

CD-SP) and those for both strengthening Pi and dissolving phlegm (CD-SPDP) in inhibiting obesity. Excepting eight rats allocated in the blank control group

the other 54 rats were fed with high-lipid forage for 12 weeks to establish models of obesity. Finally

30 DIO rats and 8 DIO-R rats (shown by their body weight) were obtained. The DIO rats were divided into three groups

which were given gastric perfusion

respectively

with normal saline (Group A)

CD-SP (Group B)

and CD-SPDP (Group C). Fourteen weeks later

the animals’ body weight (BW)

length (BL)

blood levels of fasting insulin (FIn)

fasting glucose (FBG)

triglyceride (TG)

cholesterol (TC)

leptin (LP)

neuropeptide Y (NPY)

C-reactive protein (CRP)

tumor necrosis factor-α(TNF-α)

adiponectin (AN)

and resistin (RS) were measured; insulin resistance index (IRI) was calculated

and the degree of obesity and lipid content in abdominal cavity of rats were estimated. Moreover

the levels of LP

CRP

TNF-α

AN and RS in homogenate of rats’ adipose tissues (ATH) were determined. After 12 weeks of high-lipid diet

the BW of DIO rats was higher than that of normal or DIO-R rats. After a 14-week continuous high-lipid diet feeding

in DIO rats

lipid coefficient (LC)

and IRI were significantly increased (P<0.01); serum levels of TNF-α

LP and AN were lower

NPY was higher

while the ATH levels of LP and AN were lower and TNF-α was higher in DIO rats than in DIO-R rats (P<0.05 or P<0.01); blood levels of FBG and lipids in DIO rats showed an increasing trend but was statistically insignificant (P>0.05); no significant difference was found in serum levels of CRP and RS due to the overly high data dispersion. Comparisons of the 3 DIO groups showed that BW

body weight index (BWI)

LC and IRI were significantly lowered after treatment (P<0.01) in Group C

while these indexes were not significantly different between Group A and B; the serum levels of TNF-α

and AN increased

NPY decreased in Group B and C

ATH levels of LP and AN increased

and TNF-α decreased in the two groups; but NPY

and AN in blood and ATH were higher in Group C than those in Group B (P<0.05 or P<0.01). CD-SPDP could inhibit DIO and IR

showing that the effect is better than that of CD-SP

and its mechanism is related to promotion of LP and AN secretion and elevation of serum NPY.

Abstract

To observe the difference in fatty degree

glucose-lipid disorder and adipose-hormones between diet induced obesity (DIO) rats and diet induced obesity resistance (DIO-R) rats

and to explore the effect and acting mechanism of Chinese drugs for strengthening Pi (脾

CD-SP) and those for both strengthening Pi and dissolving phlegm (CD-SPDP) in inhibiting obesity. Excepting eight rats allocated in the blank control group

the other 54 rats were fed with high-lipid forage for 12 weeks to establish models of obesity. Finally

30 DIO rats and 8 DIO-R rats (shown by their body weight) were obtained. The DIO rats were divided into three groups

which were given gastric perfusion

respectively

with normal saline (Group A)

CD-SP (Group B)

and CD-SPDP (Group C). Fourteen weeks later

the animals’ body weight (BW)

length (BL)

blood levels of fasting insulin (FIn)

fasting glucose (FBG)

triglyceride (TG)

cholesterol (TC)

leptin (LP)

neuropeptide Y (NPY)

C-reactive protein (CRP)

tumor necrosis factor-α(TNF-α)

adiponectin (AN)

and resistin (RS) were measured; insulin resistance index (IRI) was calculated

and the degree of obesity and lipid content in abdominal cavity of rats were estimated. Moreover

the levels of LP

CRP

TNF-α

AN and RS in homogenate of rats’ adipose tissues (ATH) were determined. After 12 weeks of high-lipid diet

the BW of DIO rats was higher than that of normal or DIO-R rats. After a 14-week continuous high-lipid diet feeding

in DIO rats

lipid coefficient (LC)

and IRI were significantly increased (P<0.01); serum levels of TNF-α

LP and AN were lower

NPY was higher

body weight index (BWI)

LC and IRI were significantly lowered after treatment (P<0.01) in Group C

while these indexes were not significantly different between Group A and B; the serum levels of TNF-α

and AN increased

NPY decreased in Group B and C

ATH levels of LP and AN increased

and TNF-α decreased in the two groups; but NPY

and AN in blood and ATH were higher in Group C than those in Group B (P<0.05 or P<0.01). CD-SPDP could inhibit DIO and IR

showing that the effect is better than that of CD-SP

and its mechanism is related to promotion of LP and AN secretion and elevation of serum NPY.

关键词

obesity antagonizinginsulin resistancestrengthening Pidissolving phlegmrat

Keywords

obesity antagonizinginsulin resistancestrengthening Pidissolving phlegmrat

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