Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats

Bo-jun Chen; Jing-xi Feng; Xue-xu Su; Li-qin Meng; Zhi-shang Li; Yan-li Gao; Xiao-li Xia

doi:10.1007/s11655-010-0157-1

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Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats

Updated：2021-08-27

- Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats
- Chinese Journal of Integrative Medicine Vol. 16, Issue 2, Pages: 157-161(2010)
- Affiliations：
  
  Division of Emergency, the Second Clinical College of Guangzhou University of Traditional Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-010-0157-1
  CLC：
- Published：2010，
  
  Published Online：16 May 2010，
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Chen, Bj., Feng, Jx., Su, Xx. et al. Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats., Chin. J. Integr. Med. 16, 157–161 (2010). https://doi.org/10.1007/s11655-010-0157-1

Bo-jun Chen, Jing-xi Feng, Xue-xu Su, et al. Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats. [J]. Chinese Journal of Integrative Medicine 16(2):157-161(2010)
Chen, Bj., Feng, Jx., Su, Xx. et al. Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats., Chin. J. Integr. Med. 16, 157–161 (2010). https://doi.org/10.1007/s11655-010-0157-1 DOI：

Bo-jun Chen, Jing-xi Feng, Xue-xu Su, et al. Effects of Tongguan Capsule (通冠胶囊) on post-myocardial infarction ventricular remodeling and cardiac function in rats. [J]. Chinese Journal of Integrative Medicine 16(2):157-161(2010) DOI： 10.1007/s11655-010-0157-1.

摘要

To observe the effects of Tongguan Capsule (通冠胶囊

TGC) on post-myocardial infarction ventricular remodeling and heart function in rats. A rat model of acute myocardial infarction (AMI) was established by coronary ligation. Experimental rats were randomized to 4 groups including three model groups (Group A: captopril 5 mg/kg · day

n=7; Group B: TGC 10 g/kg · day

n=7; and Group C: placebo

n=8)

and a sham-control group (Group D: blank control

n=6). Animals were treated for 4 weeks. The cardiac function of rats was assessed at the end of the experiment based on left ventricular ejection fraction (LVEF) and left ventricular short axis fractional shortening (LVFS) detected by colored echocardiography; meanwhile

the condition of ventricular remodeling was observed through the levels of left ventricular mass (LVM)

plasma aldosterone (ALD)

myocardial angiotensin II (Ang II) and myocardial collagen measurements. At the end of the experiment

LVEF and LVFS in Group A and B were improved significantly

while those in Group C were unchanged

the LVEF in Group A

and D was 0.57±0.46

0.61±0.08

0.36±0.55 and 0.76±0.02

respectively; and their LVFS was 0.31±0.52

0.34±0.04

0.23±0.57 and 0.45±0.03

respectively. The difference was statistically significant when comparing the two indexes in Group A and B with those in Group C and D (P<0.05). LVM

levels of plasma ALD and myocardial Ang II were lower in Group A and B than in Group C

but a comparison between Group A and B showed an insignificant difference in lowering LVM and ALD

while the lowering of Ang II was more significant in Group B than in Group A (754.7 ± 18.7 pg/mL vs 952.6±17.6 pg/mL

P<0.05). Morphological examination showed that in Group A and B the swollen myocardial cells had shrunk

with regularly arranged myocardial fibers and decreased collagen proliferation

but the improvements in Group B were more significant. TGC could markedly improve the post-infarction ventricular remodeling and cardiac function in rats

showing that the efficacy was better than or equal to that of captopril.

Abstract