Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats

Mei Xue; Lu Zhang; Lin Yang; Yue-rong Jiang; Chun-yu Guo; Hui-jun Yin; Ke-ji Chen

doi:10.1007/s11655-010-0247-4

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Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats

Updated：2021-08-27

- Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats
- Chinese Journal of Integrative Medicine Vol. 16, Issue 3, Pages: 247-251(2010)
- Affiliations：
  
  Center of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by National Basic Research Program of China (No. 2006CB504803)
- DOI：10.1007/s11655-010-0247-4
  CLC：
- Published：2010，
  
  Published Online：8 August 2010，
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Xue, M., Zhang, L., Yang, L. et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats., Chin. J. Integr. Med. 16, 247–251 (2010). https://doi.org/10.1007/s11655-010-0247-4

Mei Xue, Lu Zhang, Lin Yang, et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. [J]. Chinese Journal of Integrative Medicine 16(3):247-251(2010)
Xue, M., Zhang, L., Yang, L. et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats., Chin. J. Integr. Med. 16, 247–251 (2010). https://doi.org/10.1007/s11655-010-0247-4 DOI：

Mei Xue, Lu Zhang, Lin Yang, et al. Effect of Chinese herbal medicine for activating blood circulation and detoxifying on expression of inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. [J]. Chinese Journal of Integrative Medicine 16(3):247-251(2010) DOI： 10.1007/s11655-010-0247-4.

摘要

To observe the pharmaceutical effect of Chinese drugs for activating blood circulation (Xiongshao Capsule

XSC

芎芍胶囊) and for activating blood circulation and detoxification (Xiongshao Capsule and Huanglian Capsule

XSHLC

黄连胶囊) in terms of the indices of thrombosis

inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. Fifty Wistar rats were randomly divided into the sham operation group

the model group

the Simvastatin group (SG)

the activating blood circulation (ABC) group

and the activating blood circulation and detoxifying (ABCD) group

with 10 rats in each group. Simvastatin (1.8 mg/kg)

XSC (0.135 g/kg) and XSHLC (0.135 g/kg) were administered to Simvastatin

ABC and ABCD group by gastrogavage

and an equal volume of normal saline was given to the sham operation group and the model group. After 2 weeks of successive medication

the rats in the model and all drug therapy groups were made into experimental carotid artery thrombosis model. The serum levels of matrix metalloproteinases (MMP-9)

tissue inhibitors to metalloproteinase (TIMP-1)

granule membrane protein-140 (GMP-140)

tissue-type plasminogen activator (t-PA)

high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were detected with enzyme-linked immunoassay 24 h later. Compared with the model group

the levels of serum GMP-140

hs-CRP

IL-6 and MMP-9 were significantly decreased

and the level of t-PA was significantly increased in the ABC and ABCD group ( P<0.05)

while the level of serum hs-CRP in ABCD group decreased significantly compared with that in the ABC group (P<0.05). Chinese drugs both for activating blood circulation and for activating blood circulation and detoxifying have good effects on regulating indices of thrombosis

inflammatory reaction and tissue damage in experimental carotid artery thrombosis rats. The effect of activating blood circulation and detoxifying drugs on regulating the level of serum hs-CRP is superior to that of activating blood circulation drug alone.

Abstract

To observe the pharmaceutical effect of Chinese drugs for activating blood circulation (Xiongshao Capsule

XSC

芎芍胶囊) and for activating blood circulation and detoxification (Xiongshao Capsule and Huanglian Capsule

XSHLC

黄连胶囊) in terms of the indices of thrombosis

inflammatory reaction and tissue damage related factors in experimental carotid artery thrombosis rats. Fifty Wistar rats were randomly divided into the sham operation group

the model group

the Simvastatin group (SG)

the activating blood circulation (ABC) group

and the activating blood circulation and detoxifying (ABCD) group

with 10 rats in each group. Simvastatin (1.8 mg/kg)

XSC (0.135 g/kg) and XSHLC (0.135 g/kg) were administered to Simvastatin

ABC and ABCD group by gastrogavage

and an equal volume of normal saline was given to the sham operation group and the model group. After 2 weeks of successive medication

the rats in the model and all drug therapy groups were made into experimental carotid artery thrombosis model. The serum levels of matrix metalloproteinases (MMP-9)

tissue inhibitors to metalloproteinase (TIMP-1)

granule membrane protein-140 (GMP-140)

tissue-type plasminogen activator (t-PA)

high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were detected with enzyme-linked immunoassay 24 h later. Compared with the model group

the levels of serum GMP-140

hs-CRP

IL-6 and MMP-9 were significantly decreased

and the level of t-PA was significantly increased in the ABC and ABCD group ( P<0.05)

关键词

activating blood circulationactivating blood circulation and detoxifyingthrombosistissue damageinflammatory reaction

Keywords

activating blood circulationactivating blood circulation and detoxifyingthrombosistissue damageinflammatory reaction

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Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Department of Pharmacology, College of Pharmaceutical Science, Soochow University

Experimental Center of Medical and Biological Teaching, Medical College of Soochow University

Institute of Pharmaceutical Research in Yangzhou University

Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong Medical University School of Medicine

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