Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture

Ming-xia Wu; Xi-hai Li; Mu-nan Lin; Xi-rui Jia; Rong Mu; Wen-rong Wan; Rui-hua Chen; Li-hua Chen; Wan-qing Lin; Cong-yang Huang; Xue-ru Zhang; Kun-da Hong; Li Li; Xian-xiang Liu

doi:10.1007/s11655-010-0513-1

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Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture

Updated：2021-08-27

- Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture
- Chinese Journal of Integrative Medicine Vol. 16, Issue 4, Pages: 291-297(2010)
- Affiliations：
  
  1. The Second People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. The Integrative Institute of Fujian University of Traditional Chinese Medicine,Fuzhou,China
  3. Fuzhou General Hospital of Nanjing Military Area,Fuzhou,China
  4. Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan,China
  5. Union Hospital of Fujian Medical University,Fuzhou,China
  6. Xiamen Municipal Hospital of Traditional Chinese Medicine,Fujian Province,China
  7. Fuzhou Municipal Hospital of Integrative Medicine,Fuzhou,China
  8. Bao’an District Hospital of Traditional Chinese Medicine,Guangdong Province,Shenzhen,China
  9. Fujian Provincial People’s Hospital,Fuzhou,China
  10. Quanzhou Municipal Hospital of Traditional Chinese Medicine,Fujian,China
  11. Xinjing County Hospital of Traditional Chinese Medicine,Sichuan Province,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30873277) and the CHEN Ke-ji Development Fund of Integrative Medicine (No. CKJ2008003)
- DOI：10.1007/s11655-010-0513-1
  CLC：
- Published：2010，
  
  Published Online：10 August 2010，
Scan for full text
Wu, Mx., Li, Xh., Lin, Mn. et al. Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture., Chin. J. Integr. Med. 16, 291–297 (2010). https://doi.org/10.1007/s11655-010-0513-1

Ming-xia Wu, Xi-hai Li, Mu-nan Lin, et al. Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture. [J]. Chinese Journal of Integrative Medicine 16(4):291-297(2010)
Wu, Mx., Li, Xh., Lin, Mn. et al. Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture., Chin. J. Integr. Med. 16, 291–297 (2010). https://doi.org/10.1007/s11655-010-0513-1 DOI：

Ming-xia Wu, Xi-hai Li, Mu-nan Lin, et al. Clinical study on the treatment of knee osteoarthritis of Shen (肾)-Sui (髓) insufficiency syndrome type by electroacupuncture. [J]. Chinese Journal of Integrative Medicine 16(4):291-297(2010) DOI： 10.1007/s11655-010-0513-1.

摘要

To study the clinical effificacy of electroacupuncture (EA) on treating knee osteoarthritis (KOA) of Shen (肾)-Sui (髓) insuffificiency (SSI) syndrome type. A total of 245 patients (279 knees) of KOA-SSI were randomly assigned to two groups by lottery: 141 knees in the treatment group and 138 knees in the control group. The treatment group was managed with EA at the dominant points of Neixiyan (Ex-LE4) and Waixiyan (Ex-LE5) as well as the conjugate points of Xuanzhong (GB39) and Taixi (KI3) for 30 min

once a day

with 15 days as one course; 2 courses were applied with a 5-day interval in between. The control group was treated with intra-articular injection of 2 mL hyaluronic acid into the affected joint every 7 days for 5 times in total. The clinical effects on the patients in different stages were observed

and their symptom scores of knee and contents of cytokines

including interleukin-1 (IL-1)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

prostaglandin E2α (PGE2α) and matrix metalloproteinases-3 (MMP-3)

in the knee joint fluid were measured before and after treatment. The study was completed in 235 patients (263 knees); four patients (7 knees) in the treatment group and six patients (9 knees) in the control group dropped out. Comparison of therapeutic effects (excellent and effective rates) between the two groups showed insignificant differences (P>0.05). Symptom scores of knee and contents of cytokines in the knee flfluid after treatment were lowered signifificantly in the patients of stage I–III in both groups (P<0.05 or P<0.01). However

the lowering of the total symptom score of knee in the patients of stage III in the treatment group was more signifificant (P<0.05). EA could effectively alleviate the clinical symptoms in KOA patients of stage III

showing an effect superior to that of hyaluronic acid. EA also shows action in suppressing the secretion of IL-1

IL-6

TNF-α

PGE2α and MMP-3 in the knee flfluid.

Abstract

once a day

and their symptom scores of knee and contents of cytokines

including interleukin-1 (IL-1)

interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

prostaglandin E2α (PGE2α) and matrix metalloproteinases-3 (MMP-3)

showing an effect superior to that of hyaluronic acid. EA also shows action in suppressing the secretion of IL-1

IL-6

TNF-α

PGE2α and MMP-3 in the knee flfluid.

关键词

osteoarthritiselectroacupunctureclinical effectivenesscytokine

Keywords

osteoarthritiselectroacupunctureclinical effectivenesscytokine

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Department of Integrated Chinese and Western Medicine, West China Hospital of Sichuan University

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Wangjing Hospital, China Academy of Chinese Medical Sciences

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