Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage

Hui Liao; Jie Xu; Zhan-zeng Lin; Jia-yue Yang; Qiang Chen

doi:10.1007/s11655-010-0514-0

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Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage

Updated：2021-08-27

- Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage
- Chinese Journal of Integrative Medicine Vol. 16, Issue 4, Pages: 304-308(2010)
- Affiliations：
  
  Department of Integrative Chinese and Western Medicine, the Forth Central Hospital of Tianjin City,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the Special Fund for Integrative Chinese and Western Medical Researches of Tianjin City (No. 07057)
- DOI：10.1007/s11655-010-0514-0
  CLC：
- Published：2010，
  
  Published Online：10 August 2010，
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Liao, H., Xu, J., Lin, Zz. et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage., Chin. J. Integr. Med. 16, 304–308 (2010). https://doi.org/10.1007/s11655-010-0514-0

Hui Liao, Jie Xu, Zhan-zeng Lin, et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage. [J]. Chinese Journal of Integrative Medicine 16(4):304-308(2010)
Liao, H., Xu, J., Lin, Zz. et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage., Chin. J. Integr. Med. 16, 304–308 (2010). https://doi.org/10.1007/s11655-010-0514-0 DOI：

Hui Liao, Jie Xu, Zhan-zeng Lin, et al. Effect of Tianhuang Granule (田黄冲剂) on intracranial pressure and serum matrix metalloproteinase-9 in patients with acute cerebral hemorrhage. [J]. Chinese Journal of Integrative Medicine 16(4):304-308(2010) DOI： 10.1007/s11655-010-0514-0.

摘要

To study the effect and mechanism of Tianhuang Granule (田黄冲剂

THG) on: hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring

serum matrix metalloproteinase-9 (MMP-9) level observation

and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function de ficit). Sixty patients with ACH were equally randomized: into two groups by lottery

the control group and the THG group; all were treated with conventional therapy

but to the patients in the THG group

THG was given orally in addition for 28 days. Changes of ICP

MMP-9 expression

and NIHSS scores

as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients

were estimated and compared. (1) ICP was lowered more significantly in the: THG group

showing a significant difference between groups on day 7 (P<0.05). (2) MMP-9 expression was down-regulated in the THG group more significantly and earlier than that in the control group. (3) The degrees of cerebral hematoma and hydrocephalus in the THG group on day 7 were reduced significantly as compared with those on day 3 (P<0.05)

but in the control group

the day of significant reduction was delayed to day 14

and the degrees on day 7 and day 14 in the two groups were significantly different (P<0.05 and P<0.01). (4) NIHSS score was significantly lower in the THG group than that in the control group on day 14 and day 28 (P<0.05 and P<0.01). THG can effectively lower ICP

down-regulate MMP-9 expression

promote the absorption: of cerebral hematoma and hydrocephalus

and improve the nerve function

showing a clinical effectiveness than conventional therapy.

Abstract

To study the effect and mechanism of Tianhuang Granule (田黄冲剂

THG) on: hydrocephalus in the patients with acute cerebral hemorrhage (ACH) through intracranial pressure (ICP) monitoring

serum matrix metalloproteinase-9 (MMP-9) level observation

and National Institutes of Health Stroke Scale (NIHSS) scoring (for nerve function de ficit). Sixty patients with ACH were equally randomized: into two groups by lottery

the control group and the THG group; all were treated with conventional therapy

but to the patients in the THG group

THG was given orally in addition for 28 days. Changes of ICP

MMP-9 expression

and NIHSS scores

as well as the degree of cerebral hematoma and hydrocephalus (by cranial CT scanning) in the patients

were estimated and compared. (1) ICP was lowered more significantly in the: THG group

but in the control group

the day of significant reduction was delayed to day 14

down-regulate MMP-9 expression

promote the absorption: of cerebral hematoma and hydrocephalus

and improve the nerve function

showing a clinical effectiveness than conventional therapy.

关键词

acute cerebral hemorrhageintracranial pressurematrix metalloproteinase-9hydrocephalusChinese medicinal therapyTianhuang Granule

Keywords

acute cerebral hemorrhageintracranial pressurematrix metalloproteinase-9hydrocephalusChinese medicinal therapyTianhuang Granule

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Department of Traditional Chinese Medicine, the 2nd Xiangya Hospital, Central South University

Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University

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Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences

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