Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤)

Yong Li; Lei Wang; Chao Su; Huan-na Sun

doi:10.1007/s11655-010-0519-8

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Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤)

Updated：2021-08-27

- Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤)
- Chinese Journal of Integrative Medicine Vol. 16, Issue 4, Pages: 348-352(2010)
- Affiliations：
  
  Department of Hepatopathy, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,China
- Author bio：
- Funds：
  
  Supported by the Keystone Item of Shandong Provincial Science and Technique Development Plan (No. 2007GG 2NS02076)
- DOI：10.1007/s11655-010-0519-8
  CLC：
- Published：2010，
  
  Published Online：10 August 2010，
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Li, Y., Wang, L., Su, C. et al. Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤)., Chin. J. Integr. Med. 16, 348–352 (2010). https://doi.org/10.1007/s11655-010-0519-8

Yong Li, Lei Wang, Chao Su, et al. Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤). [J]. Chinese Journal of Integrative Medicine 16(4):348-352(2010)
Li, Y., Wang, L., Su, C. et al. Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤)., Chin. J. Integr. Med. 16, 348–352 (2010). https://doi.org/10.1007/s11655-010-0519-8 DOI：

Yong Li, Lei Wang, Chao Su, et al. Clinical observation on the treatment of chronic severe hepatitis B by retention enema with Huchang Jiedu Decoction (护肠解毒汤). [J]. Chinese Journal of Integrative Medicine 16(4):348-352(2010) DOI： 10.1007/s11655-010-0519-8.

摘要

To observe the efficacy of retention enema with Huchang Jiedu Decoction (护肠解毒汤

HJD) in treating chronic severe hepatitis B (CSHB). Sixty patients of CSHB were equally randomized into the treated group and the control group. Both groups were treated with conventional integrative medicine

but to patients in the treated group

retention enema with HJD was given in addition

once every day for 3 weeks. The dominant symptoms

physical signs

and related biochemical indices

as well as the incidence of complications in patients before and after treatment

were observed. Good therapeutic effects were shown in the treated group

with a total effective rate better than that in the control group (83.3% versus 60.0%

P<0.05)

superior in terms of lowering alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

total bilirubin (TBil)

globulin (Glb)

and endotoxin (ET) levels and increasing prothrombin activity (PTA)

total cholesterol (TC)

and calcium (Ca) levels

as well as eliminating ascites and preventing hepatic encephalopathy (P<0.05); especially in treating middle/early stage patients with Chinese medicine syndrome differentiated as water-toxin accumulation pattern. Retention enema with HJD is surely effective in treating CSHB

and its primary mechanism may be related to the mitigation of enterogenous endotoxemia.

Abstract

To observe the efficacy of retention enema with Huchang Jiedu Decoction (护肠解毒汤

but to patients in the treated group

retention enema with HJD was given in addition

once every day for 3 weeks. The dominant symptoms

physical signs

and related biochemical indices

as well as the incidence of complications in patients before and after treatment

were observed. Good therapeutic effects were shown in the treated group

with a total effective rate better than that in the control group (83.3% versus 60.0%

P<0.05)

superior in terms of lowering alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

total bilirubin (TBil)

globulin (Glb)

and endotoxin (ET) levels and increasing prothrombin activity (PTA)

total cholesterol (TC)

and calcium (Ca) levels

and its primary mechanism may be related to the mitigation of enterogenous endotoxemia.

关键词

Huchang Jiedu Decoctionsevere hepatitistype BRetention Enemaendotoxemia

Keywords

Huchang Jiedu Decoctionsevere hepatitistype BRetention Enemaendotoxemia

references

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Department of Digestive Diseases, The 4th Hospital Affiliated to Harbin Medical University

The second Affiliated Hospital of Harbin Medical University

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Department of Endocrinology, Traditional Chinese Medcine Hospital of Xinjiang Uigur Municipality

First Hospital of Peking University

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